Injecting fractalkine into mouse models of multiple sclerosis increased the number of oligodendrocytes. Findings suggest fractalkine may help to slow the progression, or potentially halt Multiple Sclerosis.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neuroimmunology #Neuroinflammation #Demyelination #DemyelinatingDiseases #MultipleSclerosis #Oligodendrocytes #Fractalkine

https://neurosciencenews.com/multiple-sclerosis-fractslkine-222344/

New research shows that the drug Riluzole, approved by the U.S. Food and Drug Administration to treat certain forms of amyotrophic lateral sclerosis, can at least partially correct the molecular cause of some leukodystrophies.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #RareDiseases #Leukodystrophies #Demyelination #DemyelinatingDiseases #Riluzole

https://neurosciencenews.com/myelin-neuropharmacology-21997/

🔴 Demyelinating Diseases

🔸 The #glialcells that make the myelin are of different types that make it (myelin) in the central nervous system and in the peripheral nervous system. And because of that, people who get a demyelinating disease, get it either in the central nervous system or in the peripheral nervous system -- but not in both.

🔸 So the problem is either in the #oligodendrocytes (and the interaction between the oligodendrocytes and the axon) -- in which case you get a central demyelinating disease, and the most common by far is multiple #sclerosis -- or there's a problem in the #SchwannCell and its connection to the axon, and in that case you can get a variety.

🔸 There are a diverse group of hereditary neuropathies called Charcot-Marie Tooth, which are #DemyelinatingDiseases. They're inherited and they typically progress and become worse with time.
🔸 There's also an acute demyelinating disease called Guillain–Barré, which typically has a very quick onset, it's inflammatory, and luckily it goes away after a while.