"Overall, our study suggests that the ongoing selective pressures exerted on parasite populations in Ethiopia by HRP2-based RDT diagnosis and ACT treatment might result in co-occurrence of diagnostic and drug resistance, representing a double threat to #malaria elimination."

#Plasmodium falciparum resistant to #artemisinin and diagnostics have emerged in Ethiopia

https://www.nature.com/articles/s41564-023-01461-4

#AMR

"Resistance selection in Uganda may also have been furthered by the use of #artemisinin monotherapy, with the artemisinin component unprotected by a long-acting partner drug. The use of artemisinin monotherapy to treat uncomplicated malaria has been discouraged, but the practice persists."

Evolution of Partial Resistance to Artemisinins in #Malaria Parasites in Uganda

https://www.nejm.org/doi/full/10.1056/NEJMoa2211803

#IDMastodon #InfectiousDiseases #AMR

#Artemisinin is amazing!

https://newstarget.com/2023-06-30-who-artemisinin-powerful-remedy-against-malaria.html

#malaria #remedy

#Artemisinin is amazing!

https://www.naturalnews.com/2023-06-30-who-artemisinin-powerful-remedy-against-malaria.html

#malaria #remedy

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#health #holistichealing #holistichealthsolutions #holistictreatment #holistictherapy #artemisia #artemisinin #cancer #cancerremedy #painrelief #inflammation #parasite #pathogenfighter #bacteria #worms #immunesystem #digestion #diabetes #neuroprotective #malaria

Our March issue is online!

This month’s cover highlights 2 articles on #GutMicrobiota dysfunctions in #myopathies.

Read also our review on peritoneal metastases & articles on a new PDX model for #melanoma, #AlcoholicLiverInjury, infancy-onset #diabetes, #MultipleSulfataseDeficiency, #Artemisinin in #BrainTumors & much more!

🗞️ Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/3

Happy Monday!
Online today: A whole-genome scan for #Artemisinin cytotoxicity reveals a novel therapy for human #BrainTumors

By J. Taubenschmid-Stowers, JM Penninger & colleagues
@IMBA_Vienna @UBC

Read 🗞️ #openaccess: https://doi.org/10.15252/emmm.202216959

This looks pretty interesting.

"Overall, the findings indicate that different incidences favor different k13 mutations, explaining the occurrence of different mutations in different geographical regions."

Impact of different mutations on Kelch13 protein levels, ART resistance and fitness cost in _Plasmodium falciparum_ parasites

#malaria #amr #evolution #artemisinin

https://www.biorxiv.org/content/10.1101/2022.05.13.491767v5?ct=

First identification of Plasmodium falciparum #artemisinin resistance in the UK (ex Uganda)

#Malaria #GlobalHealth

https://www.gov.uk/government/collections/malaria-reference-laboratory-mrl

On the worsening #AntiMalarial #DrugResistance in #Africa

#malaria #drugs #artemisinin #PlasmodiumFalciparum #Plasmodium #falciparum #protozoa #Anopheles #mosquito

https://www.dw.com/en/africa-antimalarial-drug-resistance-on-the-rise/a-64306141

New research article in The Lancet> Pregnancy outcomes after first-trimester treatment with #artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01881-5/fulltext#.Y4SAJ2S_2Xk.twitter #malaria

Hello #medmastodon #epitwitter #epidemiology, how does drug-resistance evolve to combination therapies? For #malaria this is a critical question, as #artemisinin-based combination therapies (ACTs) are now used worldwide, and drug-resistance evolves to both the artemisinins and the non-artemisinin partner drugs. A first thread attempt on mastodon. 1/

https://news.cgtn.com/news/2022-04-27/Traditional-Chinese-medicine-is-helping-healing-an-ailing-world-19zJfT8bepO/index.html

#artemisinin (sweet wormwood)(artemisia annua) #covid

“Indeed, it is a fact that has been proven yet again in the country’s fight against the COVID-19 pandemic.”
+
https://articlefeed.org/sweet-wormwood-again-shows-effectiveness-against-covid-19/
+
https://www.naturalproductsinsider.com/herbs-botanicals/herb-discovered-have-activity-against-sars-cov-2-virus

Ric Scalzo Institute for Botanical Research
Southwest College of Naturopathic Medicine
Tempe Arizona