@PhiloNeuroScie

“To expand the repertoire of endogenous cellular communication, we developed a synthetic, photon-assisted synaptic transmission (PhAST) system. PhAST is based on luciferases and channelrhodopsins that enable the transmission of a neuronal state across space, using photons as neurotransmitters.”

Porta-de-la-Riva et al. 2023 https://www.nature.com/articles/s41592-023-01836-9

What a fun project and cool finding, and made in #Catalunya to top it off at the Photonic Science Institute.

Combine that with #photopharmacology and neural circuits may be able to dose themselves according to activity patterns.

#neuroscience #PhAST #Luciferase #ChannelRhodopsin #biophotonics #optogenetics

All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

•All-optical modulation/readout of membrane voltage in hippocampal plasticity (BTSP)

•Cellular-resolution all-optical measurements reveal synaptic potentiation in BTSP

•Cellular-resolution all-optical measurements reveal no excitability changes in BTSP

•Presynaptic (CA2/3) region activity required for full postsynaptic (CA1)-induced BTSP

https://www.cell.com/cell/fulltext/S0092-8674(22)01578-1

#optogenetics #GEVI #channelrhodopsin #nomoa