#Cohesin can resolve sister #chromatids already in G2 phase independent of #condensin - suggesting DNA #loopextrusion as generic mechanism for segregating #replicated genomes shared across different Structural Maintenance of #Chromosomes (SMC) protein complexes

Paul Batty, Daniel Gerlich et al #viennabiocenter
https://www.embopress.org/doi/10.15252/embj.2023113475

Another fruitful @viennabiocenter collaboration, in this case with @golobor @IMBA_Vienna. #cohesin #immunoglobolin #DNA #chromatin #antibody

CTCF binds to DNA and acts as a barrier to #cohesin, regulating its activity and restraining loop extrusion to specific areas of the genome. But how?
Read our news release to find out.👀⏬ (2/)
https://www.imp.ac.at/news/article/architects-of-the-genome

Referenced link: https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1641149993682599944#m

Understanding how #cohesin makes #DNA loops in the human genome and its role in Cornelia de Lange syndrome @CNIO_Cancer @NatureComms https://www.nature.com/articles/s41467-023-36900-7 https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html

RT @IMPvienna
The labs of Jan-Michael Peters and @leonidmirny @MIT have found how #genetranscription interferes with #cohesin-mediated loop extrusion. Transcription shapes genome organisation in unexpected ways!
The paper: https://www.pnas.org/doi/10.1073/pnas.2210480120
Our news article: https://www.imp.ac.at/news/article/gene-transcription-hampers-cohesins-travel-along-chromosomes

The labs of Jan-Michael Peters and @leonidmirny @MIT have found how #genetranscription interferes with #cohesin-mediated loop extrusion. Transcription shapes genome organisation in unexpected ways!
The paper: https://www.pnas.org/doi/10.1073/pnas.2210480120
Our news article: https://www.imp.ac.at/news/article/gene-transcription-hampers-cohesins-travel-along-chromosomes

Our latest work on computer simulation of #chromatin appeared in its final form today. Fully extruded loops mediated by #cohesin and #CTCF have increased contact probabilities within loops. Microloops manifest without additional factors. Effects depend on nucleosome positions. It is freely available online until end of the year with https://authors.elsevier.com/a/1g4Hg1SPT0FkK

IF you want to get a quick idea what we are working on see the talk of my PhD student Aymen Attou on youtube at the "Nuclear architecture & Function" symposium in Toulouse #chromatin #ctcf #cohesin

I am excited to be at genomic.social #introduction. I am interested in understanding the spatial structure of #chromatin and its regulation e.g. by nucleosome positions or #cohesin. My lab uses Monte Carlo simulations with a resolution of single nucleosomes of regions up to 1 Mbp.