#IDMastodon #NeuroCOVID Four decades of ME/CFS research: what Long COVID researchers can learn. Following up on 31,486 symptomatic infections for 18 months, it was determined that 1856 (6 %) had not recovered & 13,350 (42%) had recovered only partially. ‘PASC’in the RECOVER protocols is ongoing, relapsing, or new symptoms,or other health effects occurring after the acute phase (4- more weeks)of #SARSCoV2 infection & those with persistent symptoms that cannot be explained by major organ injuries

#IDMastodon #NeuroCOVID Almost individuals who infected w #SARSCoV2 lose senses of taste & smell. 🦠 gets inside neurons through the nose. Knowing that 🦠 can infected & probably altered the function of every cells & leave the extensive damages to the host immunity on it’s path ,esp 🧠 & #sensoryneurons . #MaskUp 😷 #CovidIsNotOver
https://www.cell.com/iscience/fulltext/S2589-0042(23)01767-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223017674%3Fshowall%3Dtrue

@virusesmdpi #IDMastodon In the aggressive marching of #Eris .There is two important investments to safe your life are #MaskUp😷 & #COVID19Vaccination .#CovidIsNotOver . #SARSCoV2 reservoir may drive inflammatory, coagulation, microbiome, neuroimmune and other abnormalities in #neurocovid / #LongCovid .

#IDMastodon #NeuroCOVID where is #bloodclots in #LongCovid ? The ongoing hunt for mechanisms underlying LC has yielded several possible culprits, including excess 🩸 clotting, rampant inflammation, and persistence of #SARSCoV2 in the body. Several studies have also proposed potential biomarkers . Many people develop neuropsychiatric symptoms in the weeks & months post Covid , in isolation or within a #postacuteCOVID19 syndrome- LC.

Up to 1/3 of individuals who survived acute #COVID19 infection will develop symptoms persisting longer than 6 weeks, known as LC or #PASC. Many individuals with PASC experience neurologic symptoms : cognitive impairment,fatigue, ANS disturbances, myalgia, headache, & other pain syndromes, #neurocovid . Most patients with NP experience mild and transient respiratory symptoms of #COVID19 and do not require hospitalization during the acute infection.

#IDMastodaon #NeuroCovid MedSky🧪The more I learned about #SARScoV2🦠 and their destructive doing to the host immunity , the more further distance away that i keep from the crowd & 😷would never leave my face .Especially in the wakes of Eris and Pirola .#CovidIsNotOver . An increasing number of reports suggest an association between #SarsCoV2 infection and initiation or acceleration of #neurodegenerativediseases ( #Alzheimersdisease & #CreutzfeldtJakobdisease )

While many vaccinated cases result in mild symptoms , #COVID disruption to work and life is still undeniable. Plus, some evidence suggests that each subsequent bout of the virus may raise the risk of experiencing a persistent state of exhaustion ,#neurocovid or #LongCovid . Consistent 😷 has been shown to be an accessible and effective means to reduce transmission, whether you’re at risk of unknowingly spreading the virus or of contracting it. vaccinations and boosters are vital also

#IDmastodon #CovidIsNotOver and it’s worthy of any seconds to protect your precious quality of life by 😷 up and don’t let #COVID19 take it away from you esp #Neurocovid .In this study hyposmia was the first clinically presenting symptom in around 12% of patients. In most cases, recovery is spontaneous within 3 to 4 weeks However, some patients develop persistent olfactory impairment up to 12 moth after #COVID infection, suggesting that the damage to the olfactory sys may be severe or permanent .

#IDMastodon #neurocovid #SarsCoV2 is neurotropic, with deleterious consequences for the blood–brain barrier integrity and central nervous system cells, which could underlie neurological disorders following #SarsCoV2 infection.
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02861-3

#IDMastodon #CovidIsNotOver #NeuroCovid . 😷up & mind that #viralload .It may shrink your 🧠.Impact of mild #SARSCoV2 infection may shrink several parts of the brain
📌 https://www.sciencedirect.com/science/article/pii/S0149763423001197
📌 https://www.sciencedirect.com/journal/neuroscience-and-biobehavioral-reviews/vol/149/suppl/C

#IDMastodon #NeuroCovid #SARSCoV2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. TMEM106B, a lysosomal transmembrane protein, can serve as an alternative receptor for SARS-CoV-2 entry into #ACE2-negative cells. As a type II transmembrane protein, comprising 274 amino acid residues,

#IDMastodon #neurocovid #SARSCoV2 Infection and Dysregulation of Dopamine Neurotransmission
📌 https://www.mdpi.com/1422-0067/24/6/5618
📌 https://www.mdpi.com/2075-1729/13/2/536
📌 https://www.mdpi.com/2075-4418/13/4/687
📌 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978266/

#IDMastodon #Neurocovid #Neurobiology #viralimmunology #Neuroimmunology @cellpress #SARSCoV2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. TMEM106B, a lysosomal transmembrane protein, can serve as an alternative receptor for 🦠 entry into ACE2-negative cells .

#IDMastodon #Neuroimmunology #Neurocovid @frontimmunol
Compelling evidence for a causal effect of #COVID19 phenotype on AQP4+ NMOSD, shedding new light on the understanding of the comorbidity between #COVID19 & #neuromyelitisopticaspectrumdisorder . The underlying pathogenesis is that #SARSCoV2 infection of multiple cells, macrophages, neutrophils & dendritic cells, induces an #immuneresponse in #Tcells & #Bcells

#IDMastodon #Viralimmunology #NeuroCovid @thelancet Cognitive deficits following #SARSCoV2 infection were detectable nearly 2 years post infection, and largest for individuals with longer symptom durations, ongoing symptoms, and/or more severe infection. However, no such deficits were detected in individuals who reported full recovery from #COVID19.

what triggers long COVID?
1. Viral Persistence
2. Immune Dysregulation
3. Latent virus reactivation
4 . Autoimmunity
5. Microclots
6. Dysfunctional Neurological Signaling ( #neurocovid )
7. Disruption of the Microbiome ( Gut Dysbiosis)
The Search for Answers & The Challenges of Defining, Understanding, Addressing LC
@pfizer_news
https://www.pfizer.com/news/articles/the_challenges_of_defining_understanding_and_addressing_long_covid

#neurocovid @pratikpande15 @WesElyMD et al describe the neurological, cognitive,& #psychiatric sequelae of #COVID19-related critical illness & outline potential mitigation strategies, starting with care in the #ICU @lancetrespirmed @CIBScenter @thelancetinfdis
📌https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00238-2/fulltext
📌https://www.thelancet.com/series/post-acute-sequelae-of-COVID-19

#IDMastodon #NeuroCovid @Nature understanding the mechanism of #SarsCoV2 invading human brain , the molecular basis of #COVID19 interfering with human brain and memory, which are associated with the immune dysfunction, syncytia-induced cell death, the viral persistence , microclots and biopsychosocial aspects, the strategies for preventing the #LongCovid syndrome.
📌 https://www.nature.com/articles/s41420-023-01512-z
📌 https://www.nature.com/cddiscovery/

#IDMastodon #Neuroimmunology #Neurocovid @BrainBehavImm Recent evidence from viral RNA detection in umbilical cord blood & amniotic fluid, as well as the discovery of additional entry receptors in fetal tissues suggests a potential for viral transmission to & infection of the fetus and the potential for consequential neurological infection or inflammation in utero.. #neonates exposed to maternal #COVID19 during later development have displayed neurodevelopmental & motor skill deficiencies

#IDMastodon #NeuroCovid #Immunology #CaseReport : #Autoimmuneencephalitis with both anti-IgLON5 & anti-LGI1 receptor antibodies following #COVID19 and the clinical spectrum of encephalitis from #PostCovid .Anti-IgLON family member 5 disease is a rare autoimmune encephalitis, characterized by sleep problems, cognitive decline, gait
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1195341/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit