OpenFold, a fast, memory-efficient, and trainable implementation of AlphaFold2.
https://www.biorxiv.org/content/10.1101/2022.11.20.517210v3
#Science #ProteinStructure #StructuralBiology #MachineLearning #AlphaFold #OpenFold
#openfold #alphafold #MachineLearning #structuralbiology #proteinstructure #Science
Ars Technica: Large language models also work for protein structures https://arstechnica.com/?p=1924647 #Tech #arstechnica #IT #Technology #proteinstructure #Computerscience #biochemistry #proteins #Science #meta #AI
#Tech #arstechnica #it #technology #proteinstructure #computerscience #biochemistry #proteins #science #meta #ai
Large language models also work for protein structures - Enlarge (credit: CHRISTOPH BURGSTEDT/SCIENCE PHOTO LIBRARY)
Th... - https://arstechnica.com/?p=1924647 #proteinstructure #computerscience #biochemistry #proteins #science #meta #ai
#ai #meta #science #proteins #biochemistry #computerscience #proteinstructure
(3/3…no…4) “#Cheese with more #water 💧 or more #fat is generally softer, because those fillers space out the #protein matrix, reducing the number of #interconnections.
More mature cheese 🧀 is crumblier because its #proteinmatrix has broken down further.
A #cheddar can be somewhere in the middle, not too hard or too soft.
Varying the #proteinstructure can create almost any #texture.”
HelenCzerski, #WSJ, #EverydayPhysics
#everydayphysics #wsj #texture #proteinstructure #Cheddar #proteinmatrix #interconnections #protein #fat #water #cheese
"Patterns extracted from proteins in the Protein Data Bank (PDB) provide a ready “parts list,” circumventing the folding process entirely. These patterns are “fully baked.” That is, a pattern extracted from a solved structure in the PDB is fully preorganized; any physical–chemical organizing interactions have already been realized during folding. The situation is analogous to interpreting a movie by fast-forwarding to the final scene without first watching the previous two hours; we know how it ends, but we don’t know why."
#structuralbiology #protein #proteinstructure
Improving #proteinstructure predictions in: “A Multi-objective Cluster-based Biased Random-Key Genetic Algorithm with Online Parameter Control Applied to Protein Structure Prediction” by F Marchi, RS Parpinelli. @FedCSIS
2022, ACSIS Vol. 30 p. 337–346; http://tinyurl.com/3pn3wyr9
What's in a name?
'One of the simplest ways to classify proteins is into bins called “folded” and “unfolded”, and many of us slide into that shorthand when describing them. But it’s too simple. There are proteins that adopt a consistent three-dimensional structure that is nonetheless wrong, which are better categorized as “misfolded”, and there are proteins that have distinct regions (or sometimes the whole protein) that never adopt such a fixed structure at all, which we generally call “disordered”.'
https://www.science.org/content/blog-post/unfolding-unfolded
Interested in #AMR #superbugs and #proteinstructure? Want to do a #PhD? We have a @NLD_BBSRCDTP studentship to study #BugSlayer in #Cdiff, deadline 9 Jan https://www.findaphd.com/phds/project/piercing-the-armour-c-difficile-s-layer-permeability/?p150321
Get in touch to find out more! https://salgadolab.org/ https://pubmed.ncbi.nlm.nih.gov/35217634/
#PhDchat
#amr #superbugs #proteinstructure #phd #bugslayer #cdiff #phdchat
Biomolecules | Protein Structure | Biology | NEET 2023 | Dropper Course | VA Sir | Etoos हिंदी
With this video, students will be able to understand types of Protein Structure- primary structure, secondary structure, tertiary structure, and quaternary structure.
#proteinstructure
#etooshindimedium
#biomolecules
#proteinsecondarystructure
#tertiarystructure
#proteinstructureandfunction
#secondarystructureofprotein
#structureofaprotein
#proteinstructure #etooshindimedium #biomolecules #proteinsecondarystructure #tertiarystructure #proteinstructureandfunction #secondarystructureofprotein #structureofaprotein
Oh hey… adding some hashtags to my timeline. My interests as a dull list: #chemistry #bioinformatics #ai #ml #Proteindesign #biologics #epidemiology #immunology #aviation #stem #proteinstructure #biomanufacturing #software #chemometrics #stemjobs #drugdiscovery #drugmanufacturing
#chemistry #bioinformatics #ai #ml #Proteindesign #immunology #chemometrics #stemjobs #drugdiscovery #drugmanufacturing #biologics #epidemiology #aviation #stem #proteinstructure #biomanufacturing #software