"When you have a disease with a huge range of severity across a population, focusing policy on average impacts is severely limited in its intelligence.

Swathes of severity are ignored. Inequity multiplies. Progress impeded. Complexity blurred. Risks for vulnerable explode."

https://nitter.net/microlabdoc/status/1701142579486523819

#covid #longcovid #SARSCoV2 #pandemic #publichealth

Really excellent interview by @erictopol with my risk measurement hero or the pandemic. With transcript.

"from medical school, from all my education, we're not trained to think that viruses, especially respiratory viruses, have these myriad effects and all these organ systems."

> @erictopol 🔗 https://mstdn.social/users/erictopol/statuses/111048570993591436
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My conversation with Prof Ziyad Al-Aly on his extraordinary body of research to understand the impact of Covid

https://erictopol.substack.com/p/ziyad-al-aly-illuminating-long-covid

#LongCovid #covid19 #sars2 #sarscov2

#COVID19 Induces #Neuroinflammation & Suppresses Peroxisomes in the Brain

https://shorturl.at/dhmrZ

“The present studies point to a role of persistent neuroinflammation, especially inflammasome activation, and peroxisome biogenesis factor suppression as contributing determinants of the neurological sequelae of #COVID-19”

@longcovid #LongCovid #PwLC #PostCovidSyndrome #LC #postcovid @covid @covid19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver

New from Italy
Structural & functional impairments of skeletal muscle in patients with post-acute sequelae of #SARSCoV2 infection

https://shorturl.at/csvyX

“In our cohort of patients with #PASC, we showed limited exercise tolerance mainly due to ‘peripheral’ determinants. Substantial reductions were observed for biomarkers of mitochondrial function, content, & biogenesis”

@longcovid #LongCovid #PwLC #LC #postcovid @covid @covid19 #COVIDー19 #COVID19 #COVID #COVID_19

2/

“Fecal transplantation from #PostCovid subjects to germ-free mice led to lung inflammation & worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of #SARSCoV2 infection on the gut microbiota that persist after subjects have cleared the virus”

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC @covid
#COVIDー19 #COVID19 #COVID #COVID_19

Gut microbiota from patients with #COVID19 cause alterations in mice that resemble post-#COVID symptoms

https://shorturl.at/ipuvH

“we report the gut microbiota of #postCOVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces”

@longcovid
#LongCovid #PwLC @covid19
#COVIDー19 #COVID_19 #SARSCoV2 #novid #LC

1/

#SARSCoV2 reservoir in post-acute sequelae of #COVID19 (#PASC). Review by 33 authors

https://shorturl.at/knoUX

“we explore evidence for SARS-CoV-2 reservoir in PASC & provide context on interpretation of the findings. We delineate mechanisms by which a SARS-CoV-2 reservoir may contribute to PASC pathology & identify central research priorities & methods to guide the continued study of SARSCoV2 persistence in PASC”

@longcovid #LongCovid #PwLC #postcovid #COVIDー19 #COVID #COVID_19 #LC

New research hints at a connection between post-acute sequelae of #COVID19 & an antibody response biased against the endemic #coronavirus OC43 in rheumatic disease

https://shorturl.at/iwzJ0

“Rather than identifying an autoimmune marker of PASC, these results from 2 independent cohorts point to immunological imprinting by human endemic coronaviruses in patients with SARDs & #PASC may result in the generation of incomplete #SARSCoV2 immunity, control, & clearance”
#LongCovid #PostCovid #PwLC #LC

Reading @covid_stats (every few minutes), I get the impression that we're all on a honeymoon with #SARSCoV2 (the moment when the virus gives us peace).
One observation: this is exactly the time when a new variant can appear, with less competition.
Welcome to #BA286 #Pirola and the sub-variants already detected :covid19:
@novid

UPDATED: #Canada #SARSCoV2 variant frequencies. Updated to the week of 8/27.

As of the week of 8/27-9/1, the EG.5.1.* lineage represented 34.9% of all sequences uploaded to GISAID from Canada.

https://anarchodelphis.tumblr.com/CanadaVariants -- the graph is now usable. #COVID19

COVID patients exhale up to 1,000 copies of virus per minute during first eight days of symptoms.

The amount of virus being exhaled while infected was the same no matter which variant a person was infected with — people infected with Alpha exhaled just as much as those infected with #Omicron, the study reports.

Vaccinated and unvaccinated patients exhale similar levels of virus over the course of infection.

#Covid #Covid19 #SarsCov2

https://news.northwestern.edu/stories/2023/09/covid-patients-exhale-up-to-1000-copies-of-virus-per-minute-during-first-eight-days-of-symptoms/

UPDATED: Metro #Vancouver wastewater #SARSCoV2 signal, estimated daily new #COVID19 cases.

Both shot back up right after the Labor Day weekend.

https://anarchodelphis.tumblr.com/BCWastewater

#Burnaby #Coquitlam #RichmondBC #SurreyBC #DeltaBC #NewWestminster #Langley #WestVancouver #NorthVancouver

1. viral clearance has never been demonstrated with SARS-CoV-2
2. evidence of asymptomatic persistence has been demonstrated both in vivo and post-mortem
3. persistence is the rule, not the exception
4. reservoirs enable a subclinical form of long covid, which progresses toward a clinical form through various mechanisms, including the exhaustion of T cells and the reseeding of reservoirs upon reinfection

https://blog.open-source-eschaton.net/the-myth-of-sars-cov-2-clearance

#covid #longcovid #SARSCoV2 #pandemic #publichealth

After having simply stated the fact that #SARSCoV2 levels were rising as per last week's update, for today's update the BCCDC saw it fit to massage our interpretation wastewater data, with a concomitant fall in SARS-CoV-2 readings. Natural variance or doctoring? Unsure.

UPDATED: Island & Interior Health wastewater #SARSCoV2 signal & estimated new #COVID19 cases.

https://anarchodelphis.tumblr.com/BCWastewater

#Kelowna #Penticton #Kamloops #VictoriaBC #Nanaimo #Comox #Courtenay 1/2

“Trial By Error: Call for Retraction of Cochrane Review from Science For ME; Overview of Viral Persistence in Long #Covid; (US) Senators United on #LongCovid” by David Tuller DrPH (September 7)

http://surl.li/kxbew

@mecfs #MEcfs #CFS #MyalgicE #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome @longcovid
#PwLC #PostCovidSyndrome #postcovid @covid @covid19
#COVIDー19 #COVID19 #COVID_19 #SARSCoV2

There are signs the latest #COVID booster might only be made available to groups that are deemed high risk by our CDC.

The advisory committee is meeting Sept. 12 to decide what recommendations to make. Public comments posted by Sept. 8 will be considered in this discussion.

You can post comments here: https://www.regulations.gov/commenton/CDC-2023-0060-0001

#vaccination #SARSCoV2 #COVID #USPol

(Hat-tip to @coreo, @siderea; see https://wandering.shop/@coreo/111020927902899500)

If we want to think about the risk from #BA286 I think it's very important to keep two scenarios in mind.

We have seen #variants emerge with high variation from prior ancestors

1. that did not take off
2. that exploded

in the population. Both scenarios have happened.

The recent lab studies suggest (1) is more likely than (2). However, we don't have a great track record yet of predicting which variants will (or won't) take off.

So be careful sighing with relief over the recent "good news, it's tame" reporting. It may be right, it may not be.

We won't *know* which of these scenarios are materializing until we see waste water surveillance & hospitalization data. We can watch various bellweather countries & states for early indications.

If you are #precautionary, then it's time to get out your respirators again and reactivate your airborne precautions.

Of course, some of us have never stopped with the airborne precautions, because we can't risk making the impact we are living every day any worse.
#sars2 #sarscov2 #wave #covid19

2/2

Right now there are only

TWO (2) COMMENTS

The CDC is taking comments on a National Wastewater Surveillance System for SARSVOV2.

I think some people here might have a comment about that.

I just found this. It's not too late
!!

#WastewaterWednesday #Wastewater #Covid #SarsCoV2 #CovidIsNotOver #LongCovid

https://www.regulations.gov/document/CDC-2023-0055-0001

"However, the updated booster is not intended for everyone. It’s for people in high-risk groups – those who are age 75 or older, pregnant or immunocompromised, said Offit, who serves on the FDA’s expert panel that reviewed the vaccine companies’ data.

[...] The general public should not expect to need to receive the latest COVID booster, Offit said."

https://www.pbs.org/newshour/health/your-fall-guide-to-covid-rsv-and-flu-vaccines

They must *want* this line to keep going up 📈 :bends:

#covid #longcovid #SARSCoV2 #disability #pandemic #publichealth