The Bcl-2 inhibitor #venetoclax can selectively deplete hematopoietic stem cells and reduce radiation doses during conditioning for #StemCellTransplant in large animals, suggesting the drug could minimize toxicity and foster graft tolerance. @ScienceTM https://scim.ag/2jg #press

The Bcl-2 inhibitor #venetoclax can selectively deplete hematopoietic stem cells and reduce radiation doses during conditioning for #StemCellTransplant in large animals, suggesting the drug could minimize toxicity and foster graft tolerance. @ScienceTM https://scim.ag/2h3 #press

"Here, we utilized unbiased genetic screens to map drug/gene interactions for a variety of clinically approved therapies used in the treatment of AML. This effort highlighted a unique genetic relationship between response to venetoclax and the function of specific RNA splicing factors."

#AML #leukemia #venetoclax #BCL2 #Apoptosis #RNASplicing #AcuteMyeloidLeukemia

https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8

Recent studies have shown that #AcuteMyeloidLeukemia favors #OxPhos metabolism. This #ASH22 abstract from my colleagues demonstrates with in vitro and in vivo models that the use of #ammocidin, an inhibitor of electron transport chain complex V, works synergistically with low-dose #venetoclax to kill #AML cells. Stop by poster 2652 or read more about it here: https://ashpublications.org/blood/article/140/Supplement%201/5959/492144/Electron-Transport-Chain-Complex-V-Inhibition #leukemia #cancer #oncology #hematology #hemonc #science #medicine