@ScienceMagazine

Very interesting, too bad both articles are paywalled. Lots of potential therapeutic implications.

"Heat shock protein-47 (Hsp47) is a collagen-specific molecular chaperone, which plays an essential role in collagen synthesis and deposition to promote fibrosis"
https://doi.org/10.1038/s41392-022-01119-3

Attacks of familiar Mediterranean fever can be triggered by long duration travel. https://doi.org/10.1007/s00296-012-2453-x

#2badItsPaywalled #MedMastodon

@garry

Too bad this review paper referenced in the article is paywalled:

Psychedelics as potent anti-inflammatory therapeutics (2022)
https://doi.org/10.1016/j.neuropharm.2022.109232
"Remarkably, we have discovered that psychedelics are also potent anti-inflammatories and immunomodulators in peripheral tissues."

#2badItsPaywalled

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain

@docaustinlim

Looks interesting, #2badItsPaywalled.
Topic for a video?

Weird coincidence, today I was also looking at natural products for renal function including kuzdu / puerarin. Sometimes I like to read Amazon reviews of products & found ppl were saying it was good for alcohol cravings & headache. So I wondered if puerarin interacts w/ 5-HT2a, and indeed there is research on it -
https://doi.org/10.1254/jphs.fp0040424

Don't think I would have thought to look it up if I hadn't seen your post 1st.

@Oncologiavet

Looks interesting
#2BadItsPaywalled

#ExtracellularMatrix

In the plasma, [albumin] functions as a carrier, chaperon, antioxidant, source of amino acids, osmoregulator, etc. ... it [transports] ... free fatty acids, steroid hormones, medicines, & metal ions. As a chaperon, SA binds to & protects other proteins.
... thanks to a free sulfhydryl group, albumin is responsible for most antioxidant properties of plasma.

https://doi.org/10.1515/revneuro-2021-0165

#2badItsPaywalled 🙁 #neurodegeneration #aging #brain #albumin

Oral ingestion of dead Lactobacillus reported to stimulate interferon production in mice:

"Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice" (2009)
https://doi.org/10.1016/j.intimp.2009.04.015

#microbiome #probiotics #parabiotics
#2badItsPaywalled