Then, https://www.biorxiv.org/content/10.1101/2022.09.07.506929v1.full

Using a combination of slice #ephys and #2photon imaging the authors showed that activation of #LC noradrenergic neurons induces lateral inhibition via alpha2 adrenoreceptors.

Lateral inhibition was stronger in spatially proximal cells, and was cross-modular in its nature 👀: distinct, projection-specific #LC nodes preferentially silenced other modules, in a competition for dominance that might steer LC tonic activity in accordance to needs & circumstances