@KRHornberger

Thanks, I've read that paper!

Glad to have another option, I always enjoy your commentaries and tutorials. They remind me of my #SmallMolecule #ADME days.

Physiologically-based PK (#PBPK) models, for example, find the middle ground between PK and #QSP, having a more mechanistic bent by taking into account anatomical, physiological, physical, and chemical descriptions of the phenomena involved in complex absorption, distribution, metabolic and elimination (#ADME) processes, while remaining fundamentally driven by observed data.