A downstream effect is that this has lead to a premature halting of the FALCON trial of #Bardoxolone in #ADPKD N = 809 https://clinicaltrials.gov/ct2/show/NCT03918447

via this https://pkdcure.org/why-did-the-falcon-clinical-trial-end/

I guess the molecule is mostly dead?

5/

If #nephmadness has reinvigorated your interest in learning about kidney disease then check out this #tweetorial - emerging therapies for #ADPKD 👇👇👇
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RT @ckd_ce
1) Welcome to our new #accredited #tweetorial on Current and Emerging #Therapies in Management of #ADPKD. I am Fouad Chebib, MD, FASN (@fouadchebib), Consultant & Assistant Professor of Medicine, Nephrology & Hypertension @MayoClinicNeph, Jacksonville, FL 🇺🇸.
https://twitter.com/ckd_ce/status/1638496179540434948

RT @ckd_ce
1) Welcome to our new #accredited #tweetorial on Current and Emerging #Therapies in Management of #ADPKD. I am Fouad Chebib, MD, FASN (@fouadchebib), Consultant & Assistant Professor of Medicine, Nephrology & Hypertension @MayoClinicNeph, Jacksonville, FL 🇺🇸.

RT @ckd_ce
16) WELCOME BACK! I am @KidneyCathy & we are talking more about the management of #ADPKD in childhood!
#FOAMed #MedEd #nephtwitter
👏to @RenalFellowNtwk @Rheault_m @NephUCommunity @brendonneuen @torra_roser @MattLanktree @thePNRC @Vikas_R_D @asheetagupta @genetic_Fi @AliciaBByrne

Happy #WorldKidneyDay, everyone! The kidneys are amazing & childhood is a unique opportunity for preventative healthcare - if you'd like to learn more about the non-clinical management of #ADPKD in childhood, then check out this #tweetorial 👇👇👇
@KidneyHealth
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RT @ckd_ce
1a) Welcome to a new #accredited #tweetorial on Nonclinical Considerations in Management of #ADPKD in Childhood! Our expert author is Cathy Quinlan MD @KidneyCathy, acade…
https://twitter.com/ckd_ce/status/1633783565941895169

ADPKD is generally viewed as an adult disease but it can impact children too. Read this tweetorial to find out more 👇👇👇
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RT @ckd_ce
1) Welcome to a new #accredited #tweetorial on #childhood #ADPKD. This program is part of our ongoing series of education on ADPKD.
👉 Prior programs still available for credit at https://ckd-ce.com/category/adpkd/. Follow this 🧵for🆓 0.75hr CE/#CME!
https://twitter.com/ckd_ce/status/1630528016697761793

RT @ckd_ce
1) Welcome to a new #accredited #tweetorial on #childhood #ADPKD. This program is part of our ongoing series of education on ADPKD.
👉 Prior programs still available for credit at https://ckd-ce.com/category/adpkd/. Follow this 🧵for🆓 0.75hr CE/#CME!

RT @ckd_ce
1) Welcome to a new #accredited #tweetorial on #childhood #ADPKD. This program is part of our ongoing series of education on ADPKD.
👉 Prior programs still available for credit at https://ckd-ce.com/category/adpkd/. Follow this 🧵for🆓 0.75hr CE/#CME!

RT @ckd_ce
1) Welcome to this #accredited #tweetorial on genetic testing in the evaluation of patients with cystic kidney disease. #Kidney #cysts are a frequent finding, ranging from simple cysts to suspected or confirmed #ADPKD.
Expert author @dguerrot of @CHURouen 🇫🇷 leads us!

RT @ckd_ce
1) Welcome to this #accredited #tweetorial on #cardiovascular disorders in Autosomal Dominant Polycystic Kidney Disease. #ADPKD is widely recognized in assoc w/risk of #CKD, but has protean #cardiovascular effects as well. Expert author @dguerrot of @CHURouen 🇫🇷 leads us!

Excited to lead the @ucsdnephrology@twitter.com #ADPKD Center of Excellence. Thanks @PKDFoundation@twitter.com for this designation and the @UCSDHealth@twitter.com team for making this possible. Look forward to providing high level, comprehensive, multi-disciplinary care. @PKDFSanDiego@twitter.com
https://today.ucsd.edu/story/uc-san-diego-health-named-center-of-excellence-for-polycystic-kidney-disease

A short-term KDIs potently induce ketogenesis and are feasible for ADPKD patients in daily life. While Tota Liver Volume quickly changed upon the onset of ketogenesis, changes in Tota Kidney Volume may require longer-term interventions.

#ADPKD #endPKD
https://academic.oup.com/HTTPHandlers/Sigma/LoginHandler.ashx?error=login_required&state=0512fa51-bc1c-41d9-aded-b223903a32d6redirecturl%3Dhttpszazjzjacademiczwoupzwcomzjndtzjadvancezyarticlezyabstractzjdoizj10zw1093zjndtzjgfac311zj6845752

A short-term #KetogenicDiet potently induce ketogenesis in people with #ADPKD- #TLV quickly changes upon the onset of ketogeneses but no reduction in #TKV

https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfac311/6845752

Kidney epithelial #Tubuloid

CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling #ADPKD, Cyst size responsive to #Tolvaptan

Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities👍

Wonderful #Lumenogenesis of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel🤠

Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
https://www.nature.com/articles/s41588-022-01202-z

Statins that don't interact with #tolvaptan (according to Medscape):

- Rosuvastatin
- Fluvastatin
- Pravastatin

#ADPKD #Nephrology #NephroDon

#introduction #Nephrologist and #epidemiologist, Associate Professor at #UCSDNephrology 
Interested in #ADPKD, #biomarkers, #uromodulin, #FOAMEd, social determinants of health

Migrating over to #MedMastodon so don’t be alarmed if I re-follow you. 😀