⚤ Sex & gender differences in #ICU, influence on:
🏥 admission
🧫 #sepsis & septic shock
🫀 cardiac arrest
🫁 #ARDS
🫀 cardiogenic shock
🫘 #AKI
😵‍💫 delirium
🩺 medical treatment
🏥 general outcomes
Evidence is still scarce, and data remain conflicting. Be aware & work toward addressing them in clinical practice/research to improve management in a personalized, patient-centered manner.
Open access #FOAMcc on @ICM 🔓 https://bit.ly/483cePH

🫘 🧪 Renal biomarkers can be used to define and identify of subclinical acute kidney injury, frequent & severe condition with prognosis equivalent to that of #AKI, as defined by KDIGO criteria based on serum creatinine increase: ancillary analysis of FROG-ICU study 🐸.
Free to read #FOAMcc on @ICM
🔓 https://rdcu.be/dlsf9

Hidden information on abdominal #CTscan of patients with digestive #sepsis ?

In our monocenter cohort, we were able to predict #AKI using #RadiomicAnalysis of the kidneys.

Interesting work led by Louis Boutin, PhD candidate in our team.

https://www.accjournal.org/journal/view.php?doi=10.4266/acc.2023.00136

#CriticalCare #ICU

#AKI #斗笠菇
\毒疗！/\毒疗！/\毒疗！/

Precision management of #AKI in #ICU, current state of the art:
🫘 to clarify precision medicine concepts: sub‑phenotypes, endotypes, treatable traits
🫘 acute kidney injury? Heterogeneous syndrome (not disease!)
🫘 identification of sub‑phenotypes: strategies, challenges, limitations
🫘 proposed management approaches for specific sub‑phenotypes, emerging endotypes, treatable traits
🫘 practical recommendations according to current evidence
🖇️ https://bit.ly/3s4RJl9

🫘 EPIS #AKI, comprehensive multinational study on epidemiology of surgery associated acute kidney injury:
➡️ > 10K patients included
➡️ approximately 1/5 develop PO-AKI within 72 h after major surgery: significant burden for
health care worldwide!
➡️ patients with PO-AKI had greater ICU/hospital mortality & longer LoS
⬆️ increasing severity of PO-AKI associated with progressive increase in adverse outcomes #FOAMcc on @ICM
🖇️ https://rdcu.be/dh5zT

🫀🔪 On-support & post-weaning mortality in post-cardiotomy #ECMO:
🫀 discrepancy exists between weaning & discharge rate
🫀 on ECMO mortality = 36.6%, mostly associated with increased preop hemodynamic instability
🫀 post-weaning mortality = 23.1%. associated with higher rate of complications (re-thoracotomy, post-operative bleeding, post-op cardiac arrest, bowel ischemia, #AKI, septic shock): post-weaning care pivotal!
⬇️ Below visual abstract, results
🖇️ https://bit.ly/3D3XB0f

Acute kidney injury commonly encountered in critically ill, influencing outcomes: not only focus on prevention but also optimising treatment! In this review:
🫘 prevention
🫘 conservative management
🫘 optimal timing of initiation of RR
🫘 longer-term post #AKI follow-up
🖇️ https://bit.ly/40iHCo0

Light chain nephropathy: how to treat? #OpenAccess review from the Mayo

https://www.nature.com/articles/s41408-023-00806-w

#Free #NephPearls #Myeloma #AKI

Hidratación acorde a la diuresis para prevenir la nefropatía por contraste aguda en pacientes sometidos a procedimientos percutáneos cardiovasculares: ¿cuanto más, mejor? by Briguori, Romagnoli, et al
https://www.sciencedirect.com/science/article/pii/S1885585723000968
#AKI #RenalGuard

Diuresis-matched hydration to prevent contrast-associated acute kidney injury in patients undergoing percutaneous cardiovascular procedures: the more the merrier? by Briguori, Romagnoli, et al
https://www.sciencedirect.com/science/article/pii/S1885585723000968
#AKI #RenalGuard

Forgot to tag! #AKI #AcuteKidneyInjury

@jacek leider ist das #Tidal Profil der Band #Aki irgendwie nicht vorhanden.
Nichtsdestotrotz ist das Album #nader wirklich gut.
Aber es gibt ja auch noch z.B. #Bandcamp wo aber leider genau das Album nicht hinterlegt ist :thinking_rotate: alles etwas durcheinander.

https://akimusic6.bandcamp.com/

https://tidal.com/album/252845181

We had previously shown this to not help when it comes to post-op #AKI https://www.cmaj.ca/content/190/43/E1273

Another one from the giant Taiwan database

Propensity score matched etc

#Flozin vs DPP4i and subsequent #AKI - of course it’s less

But some info about why? See Figure 3 below

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801729 in @mike_johansen fav journal

Are these testable hypothesis @Bneuen from existing trials? (As cause of AKI)

@ChristosArgyrop @Kidney_boy

Evolution of purpura fulminans in young previously healthy woman with no comorbid condition:
🏥 #ICU admission for acute circulatory failure
📷 purpuric rash on trunk/face (course in the image)
🩸hyperlactatemia, #AKI & DIC
🧫 skin biopsy: Neisseria meningitidis serogroup Y
📖 https://rdcu.be/c49QE

PS to understand Purpura fulminans also read this review, #FOAMcc on Intensive Care Medicine
📖 https://rdcu.be/cCytD

Today we also publish new data on the laboratory parameter serum creatinine and its use in staging of acute kidney injury:

- Women and elderly patients are systematically underdiagnosed

- A sex- and age-adapted approach is necessary to address this discrimination

Our aim is to automatically identify undetected medical conditions and integrate them into the clinicians' digital workflow.

https://doi.org/10.3390/jcm12031092

#CDSS #patientsafety #AKI #KDIGO #Troponin #Creatinine

2/2

☢️ IV contrast administration in patients with pre-existing acute kidney injury: any association with persistent renal dysfunction? NOT associated with either persistent #AKI at hospital discharge or initiation of dialysis within 180 days. Findings of this retrospective propensity-weighted analysis suggest that ACR-NKF consensus recommendations
for use of IV CM in patients with stable renal disease may also be applied to patients with pre-existing AKI.
📎 https://bit.ly/3Rp023W

10 tips for #ICU management of patients post liver #transplantation
1️⃣ preoperative condition
2️⃣ intraoperative events
3️⃣ hepatic complications
4️⃣ cardiovascular management
5️⃣ acute kidney injury #AKI
6️⃣ graft rejection prevention
7️⃣ infection prophylaxis & treatment
8️⃣ nutrition management
9️⃣ early weaning from mechanical ventilation
& rehabilitation #ICUrehab
🔟 extracorporeal therapies
Free to read #FOAMcc on Intensive Care Medicine
📎 https://rdcu.be/c4plj

🟤 The few studies on #CRRT use in patients with acute liver failure have large limitations & focused mainly on its use if concomitant #AKI. CRRT membranes reduce ammonia levels and could be an adjunctive therapy, but could not be considered liver support or salvage therapy https://rdcu.be/c3X8z

🟤 In reply to https://rdcu.be/cZpbg

🟤 Refers to consensus statements for artificial liver support, in failure due to variable etiology, including graft failure after #Tx. https://rdcu.be/cU7s2