看到 #大聪看电影 中提到纪录片 #克里斯·海姆斯沃斯：挑战极限 中为 #锤哥 做的体检，其中有对 #APOE4 基因的检测，这是一项关于 #阿兹海默症 患病风险的检测。

https://youtu.be/kwq1C1ZM438

#til #video #dna #alzheimer #zh_CN

This is really intriguing - but it's VERY early in development. And if this tx is dangerous and/or staggeringly expensive, determing benefit of reducing lifetine risk from say 30-55% to 20% is going to be complicated. #Alzheimers #APOE4
Alzheimer’s APOE4 Genetic Risk Targeted in Promising Trial.
https://www.nytimes.com/2022/12/02/health/alzheimers-apoe4-gene-therapy.html

APOE4 gene & Alzheimer’s 🧠

https://www.lifehacker.com.au/2022/11/here-are-some-ways-to-reduce-the-risk-of-developing-alzheimers-even-if-you-have-the-gene/

#apoe4
#alzheimer
#dementia

RT @manoliskellis@twitter.com

This week in @Nature@twitter.com we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD

🐦🔗: https://twitter.com/manoliskellis/status/1594656572227084294

A new fascinating hypothesis about the #Alzheimersdisease:

A study has linked #APOE4 [gene variant] with faulty #cholesterol processing in the #brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. ...These changes could cause #memory and #learning deficits.
Drugs that restore the brain’s cholesterol processing could treat the disease.

#CholesterolTrafficJam
#Alzheimersgene #Alzheimer
https://www.nature.com/articles/d41586-022-03724-2

This is what #EPAD and other studies are showing. #APOE4 is such a huge risk factor for #Alzheimer's (akin to a decade of ageing) that it's basically a different, #amyloid-heavy disease. There are other routes to #Tauopathy in those with e.g. E3/E3. Paper from the great and good here https://www.nature.com/articles/s41583-021-00533-w
But if Amyloid++ 4/4 genotypes predict best response AND worse SE to anti-Amyloid therapies, shouldn't we start to TEST for it and learn how best to communicate results?