Released a bugfix to alphafold_singularity (2.3.2-1) here: https://github.com/prehensilecode/alphafold_singularity/releases/tag/v2.3.2-1 and pre-built image here https://cloud.sylabs.io/library/prehensilecode/alphafold_singularity/alphafold #alphafold

Great use of #Alphafold multimeter to screen 11k pairs of interaction between small secreted peptides from #plantPathogens and defense related hydrolases with experimental verification

https://www.biorxiv.org/content/10.1101/2023.04.03.535425v1

ChatCPT is a toy whereas AlphaFold is a genuine positive to us all.

Solve the actual big problems.

https://blog.mikeriversdale.co.nz/2023/03/ai-forget-chatgpt-alphafold-is-gold.html

#AI #ChatGPT #AlphaFold

Technology can do wonderful things!
---
RT @demishassabis
Big milestone: 1M+ researchers have now made use of #AlphaFold in their vital work, in the 18 months since we made it freely available.

From antibiotic resistance to crop sustainability, it's been amazing to see the impact of ‘Science at Digital Speed’: https://unfolded.deepmind.com/#stories
https://twitter.com/demishassabis/status/1620762940608765954

RT @ath_baltzis
Thrilled to announce the very first release of the nf-core/proteinfold pipeline!!! 🚀🚀🚀
#AlphaFold #ColabFold https://twitter.com/nf_core/status/1624096862352420888

gget implemented alphafold for its search options as well - https://github.com/pachterlab/gget

With about ~2GB of local data storage, getting alphafold (colab version) output of a protein entry can be as simple as:

import gget
gget.setup("alphafold")
gget.alphafold("PROTEINRESIDUEHERE")

Impressive stuff.

#bioinformatics #alphafold #protein

RT @DeepMind@twitter.com

Our breakthrough AI system #AlphaFold can predict the structure of almost every known protein.

We hope this will continue to help researchers make important advances in fields from drug design, to sustainability.

Find out more in @SciAm@twitter.com: https://dpmd.ai/3v4mwgi

🐦🔗: https://twitter.com/DeepMind/status/1604850768464461824

The time has come: I am running #AlphaFold for the first time! :protein:

Our lab's whiteboard.

Top: incorporating AlphaFold2 in a protein engineering pipeline.

Bottom: how to make ghee.
#ProteinEngineering
#WhiteBoardWednesday
#Alphafold #food

RT @TerwillTom@twitter.com

Wondering how accurate #AlphaFold models are?

We compared #AlphaFold predictions with experimental data. Many parts are great, but even high-confidence #AlphaFold predictions have distortions, domain movements, backbone errors, and side chain errors.

https://www.biorxiv.org/content/10.1101/2022.11.21.517405v1

🐦🔗: https://twitter.com/TerwillTom/status/1595405531891773445

@terwilltom many of those minute discrepancies are detrimental to drug discovery. I agree #AlphaFold provides a starting point for generating good theory, but that's pretty much what it can do now (we have been testing some of the models with an xxxFold-core and the mixed readout discourage us from spending more 💰 ⏱️ .)

FFS, with all due respect to #Alphafold , can someone please invent LaundryFold? We all know which problem is more time-consuming!

@msafakaragoez #AlphaFold does not capture structural changes induced by #point #mutations.

RT @IsomorphicLabs@twitter.com

Congratulations to Isomorphic Labs sister company @DeepMind@twitter.com for the inclusion of #AlphaFold on @TIME@twitter.com’s Best Inventions of 2022 list! Isomorphic Labs is building on AlphaFold to use AI to accelerate drug discovery. Join us!
https://time.com/collection/best-inventions-2022/6229912/deepmind-alphafold/

🐦🔗: https://twitter.com/IsomorphicLabs/status/1590787915252174850

RT @PDBeurope@twitter.com

Sameer Velankar, team leader @PDBeurope@twitter.com, introduces the story behind development of #AlphaFoldDB at the @emblebi@twitter.com Industry Programme Workshop on 'Applications of #AlphaFold'.
🔗http://alphafold.ebi.ac.uk

🐦🔗: https://twitter.com/PDBeurope/status/1589955622615015425

RT @embl@twitter.com

Researchers teamed up to explore how accurate and useful the #AlphaFold protein structure predictions are for different applications.

https://www.embl.org/news/science/alphafold-community-applications/

🐦🔗: https://twitter.com/embl/status/1589918331926384640