@medrxivpreprint
The commonly used #antibiotics #amoxicillin, #metronidazole, #piperacillin-tazobactam & #Clindamycin reached levels equivalent to blood within infected pleural fluid.Low penetration of trimethoprim into the pleural space raised concerns about the use of #cotrimoxazole for patients with #Pleuralinfection or parapneumonic effusions.
#Antibiotic #pharmacokinetics in infected #pleuraleffusions
https://www.medrxiv.org/content/10.1101/2023.09.08.23295282v1.full.pdf

#IDMastodon #pedsIDtwitter #IDTwitter @ISID_org Prophylactic #amoxicillin given after (A)TE in children did not show a clinically relevant effect with respect to the number oropharyngeal microorganisms as compared to placebo.
📌 https://www.sciencedirect.com/science/article/pii/S1201971223005404?dgcid=raven_sd_aip_email
📌 https://www.sciencedirect.com/journal/international-journal-of-infectious-diseases/vol/131/suppl/C

RT @IDstewardship@twitter.com

💥 📄 👀 New article!

Courtesy of 👨‍⚕️ pediatrician @MichaelCosimini@twitter.com (also the creator of 🃏 @EmpiricGame@twitter.com) here talking about the #amoxicillin shortage

📲 https://www.idstewardship.com/antibiotics-pediatric-respiratory-tract-infections-era-amoxicillin-shortages/

#IDtwitter #TwitteRx #MedTwitter

🐦🔗: https://twitter.com/IDstewardship/status/1607501536179163143

💥📄👀 New article by Dr. Cosimini @EmpiricGame giving practical insights for clinicians about the #amoxicillin shortage

https://www.idstewardship.com/antibiotics-pediatric-respiratory-tract-infections-era-amoxicillin-shortages/

Coming at ya now! A deep dive into the extreme drug shortage happening here in the United States & abroad. FDA call out, Biden admin ineffectiveness & more! Check it out here: https://youtu.be/d_HdlK6Ta7U
#drug #SHORTAGES #pharmacists #Amoxicillin #BigPharma #FDA #BidenAdministration

RT @DoctorJesseMD@twitter.com

It's getting bad out there: widespread national shortage of kids #Tylenol, #Motrin, #amoxicillin. This is what I found last night when looking for meds for my little guy @PhRMA@twitter.com @US_FDA@twitter.com @AmerAcadPeds@twitter.com

🐦🔗: https://twitter.com/DoctorJesseMD/status/1605979425127817221

Today’s #MedicineMonday is brought to you by amoxicillin-clavulanic acid. I’m both grateful we got some (baby has an ear infection) but also have been up since 4:30am due to its side effects 😅

This medication has two components:
💊 #Amoxicillin: β-lactam #antibiotic (interferes with bacterial cell walls by inhibiting peptidoglycan synthesis)
💊Potassium #clavulanate: β-lactamase inhibitor (prevents breakdown of amoxicillin, so it can stick around and do it’s job longer, and you need less of it!)

The European Medicines Agency is investigating a chronic shortage in antibiotics across Europe, where almost every country is reporting gaps in supplies.

Earlier this week, the European Center for Disease Prevention and Control and the World Health Organization warned of the rise in serious cases of invasive Strep A infections, with several children dying from the disease.

https://www.politico.eu/article/drugs-regulator-probes-eu-wide-antibiotics-shortage/

#EMA #ECDC #WHO #Antibiotics #Amoxicillin #StrepA

So, there’s a national #amoxicillin shortage. Literally, one of the most basic tools we have to fight bacterial infections is on national shortage. Add to the long list of meds on shortage (including insulin and normal saline). What’s not on shortage?
-viagra
-propecia
-botox

Why? Because pharmaceutical companies exist for profits, not for people and lawmakers refuse to intervene.

RT @leanhealth@twitter.com

#Europa ist von #Antibiotika-Knappheit betroffen -ua
#Amoxicillin, #Cephalosporine sind knapp: "Wir haben große Angst, denn wir haben gehört, dass die Knappheit drei oder vier Monate andauern wird", sagt Remi Salomon, #Kinderarzt am Necker-Enfants Malades Krankenhaus in Paris.

🐦🔗: https://twitter.com/leanhealth/status/1601614412376584192

@RainbowBody @hannu_ikonen Now what we *really* need is a pharmacist on an #antibiotic resistance mission to question all the people getting #amoxicillin for their URIs. Why don't we ever hear about those kinds of pharmacists in the outpatient world? 😆

Isotopic #sparing phenomenon on an area of #erythema migrans in #amoxicillin-induced exanthema

Free access 50 d

https://authors.elsevier.com/a/1g7hLYZNLeGi8#.Y30Md6L3qQk.twitter

#Amoxicillin shortage statement from SIDP. lets be judicious and when needed use shortest course. 5days for CAP yall. https://sidp.org/news/12978701

CHOP has some good suggestions for alternative for #Amoxicillin in context of the shortage

https://www.chop.edu/clinical-pathway/amoxicillin-suspension-shortage