#Heme biosynthesis #Angigoenesis

Roles of #EndothelialCell FLVCR1a, a heme exporter to extracellular space in
✅Developmental Angiogenesis-🐭Retina🐟ISV
✅Tumor angiogenesis
❎Vascular homeostasis

Dr. Sara Petrillo lab Angiogenesis 2023
https://link.springer.com/article/10.1007/s10456-023-09865-w

FLVCR1a deficiency-> #EndothelialCell-autonomous defects in Mitochondria, ER stress & Angiogenic behaviors

Heme accumulation triggers #Paraptosis (Organelle swelling-> Cytoplasic vacuolation)💀

Dr. Emanuela Tolosano lab Cell Death Diff 2018
https://www.nature.com/articles/s41418-017-0001-7

Other enzymes in Heme metabolism in #Angiogensis👇

Ferrochelatase is a therapeutic target for ocular neovascularization
https://www.embopress.org/doi/full/10.15252/emmm.201606561

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7

Local implant of #BMP2-loaded GelMA hydrogel improves #Osteogenesis+#Angigoenesis in rat critical-size Mandibular defect

⏫type H CD31+Emcn+ vessel
⏫Perivascular Osx+ osteoprogenitor
⏫CD51+ #SkeletalStemCell

Dr. L. Qin & J. Xu labs Pharmaceutics 2022
https://www.mdpi.com/1999-4923/14/11/2397