APOE expression and secretion are modulated by mitochondrial dysfunction

This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction

https://elifesciences.org/articles/85779

Steinzeit-Gen beeinflusst unsere Langlebigkeit. Günstige APOE-Genvarianten stammen von frühgeschichtlichen Einwanderern. #APOE #Genvariante #DNA #Steinzeit #Genetik #Lebensdauer https://www.scinexx.de/news/medizin/steinzeit-gen-beeinflusst-unsere-langlebigkeit/

New video!

A scientific review of #Limitless, #DisneyPlus and @NatGeo’s epic new series on longevity.

What’s the best thing #chrishemsworth could do for his health? Watch and find out: https://www.youtube.com/watch?v=AfFqxSwEaWs

#aging #ageing #agingbiology #biology #science #apoe #dementia #fasting

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

'Our structural, genetic, and phenotypic analyses in this large epidemiological cohort reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex and link APOE alleles to inter-individual brain structural differences indicative of ADRD familial risk.'

#Alzheimer #ApoE

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001863

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

RT @MolNeuro@twitter.com

'Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to #demyelination'

#microglia #apoe #cuprizone Na Wang, Guojun Bu, Chia-Chen Liu @MayoClinicNeuro@twitter.com

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00577-1

🐦🔗: https://twitter.com/MolNeuro/status/1595447418530979841

¿Por qué ciertas áreas del #cerebro son más vulnerables en la enfermedad de #Alzheimer ?
Algunos estudios sugieren que las partes del cerebro en las que el gen APOE (un importante factor de riesgo genético en la enfermedad de Alzheimer) es más activo son las zonas que sufren más daños.
#Neurología #Neurociencia #EnfermedadesNeurodegenerativas #APOE #Tau

https://www.infosalus.com/salud-investigacion/noticia-alzheimer-dana-ciertas-partes-cerebro-20221121163354.html

Un gen (#ApoE) que confiere riesgo de padecer la enfermedad de #Alzheimer parece estar implicado en el debilitamiento del aislamiento del "cableado" del #cerebro
#Neurociencia #Neurología #EnfermedadesNeurodegenerativas #Oligodendrocitos #Mielina

https://www.infosalus.com/mayores/noticia-gen-riesgo-alzheimer-debilita-aislamiento-cableado-cerebro-20221117072445.html

#Memory loss is often the first sign of Alzheimer’s disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to #brain tissues.
A recent study yields clues to why certain parts of the brain are particularly vulnerable to Alzheimer’s damage. It comes down to the gene #APOE, the greatest genetic risk factor for Alzheimer’s disease. The parts of the brain where APOE is most active are the areas that sustain the most damage.
#Alzheimer #NeurodegenerativeDiseases #BrainDiseases #Neurology

https://neurosciencenews.com/apoe-al