How to use your neighbours to get ahead: #glioblastoma cells use #ExtracellularVesicles to encourage neighbouring #astrocytes to secrete pro-invasive #ECM components.

#preLight from Jade Chan covering work led by Dominik Koessinger #CRUK_BI

#CancerBiology

preLight: https://prelights.biologists.com/highlights/glioblastoma-extracellular-vesicles-influence-glial-cell-hyaluronic-acid-deposition-to-promote-invasiveness/

#alzheimers #Astrocytes #Microglia
https://www.nature.com/articles/s41591-023-02380-x

RT @maglarecherche
Pour tout comprendre de ce travail de @EleonoreHardy_ et @RancillacA qui caractérise l'impact de l'expression d'une protéine exprimée par les #astrocytes sur l'activité neuronale et ouvre des perspectives thérapeutiques. @PLOSBiology
https://www.larecherche.fr/neurosciences-cerveau/la-taille-du-r%C3%A9seau-astrocytaire-est-d%C3%A9terminante-pour-l%E2%80%99activit%C3%A9-neuronale

https://alleninstitute.org/news/scishots-star-shaped-brain-cells-linked-to-ocd/
#Astrocytes #OCD

Upregulation of #connexin 30 in #astrocytes increases connectivity of #astroglial networks, but decreases synaptic transmission, altering #SynapticPlasticity & learning processes @EleonoreHardy_ @NathalieRouach @RancillacA &co #PLOSBiology https://plos.io/3UrHRMx

Upregulation of #connexin 30 in #astrocytes increases connectivity of #astroglial networks, but decreases synaptic transmission, altering #SynapticPlasticity & learning processes @EleonoreHardy_ @NathalieRouach @RancillacA &co #PLOSBiology https://plos.io/3UrHRMx

Further studies are needed to understand their full contribution to neurodegeneration. #neurodegenerative #astrocytes

RT @SRBR_Outreach
Are #astrocytes under-appreciated in their role in brain function and circadian rhythms? This @AnnualReviews Neuroscience by Hastings, @MarcoBrancacci4, Gonzalez-Aponte and @ErikHerzog seeks to redress the balance:

https://www.annualreviews.org/doi/abs/10.1146/annurev-neuro-100322-112249

Are #astrocytes under-appreciated in their role in brain function and circadian rhythms? This @AnnualReviews Neuroscience by Hastings, @MarcoBrancacci4, Gonzalez-Aponte and @ErikHerzog seeks to redress the balance:

https://www.annualreviews.org/doi/abs/10.1146/annurev-neuro-100322-112249

@PhiloNeuroScie Wow, linking neuromodulation with glia and the synchrony of neuronal activity. How interesting. It's giving me ideas for experiments to run in #Drosophila to study the contributions of astrocyte-like glial cells.

#neuroscience #astrocytes #glia

RT @sadagurski
@sadagurski's lab is HIRING!! We are looking for a talented #postdoc interested in the hypothalamic regulation of metabolism, and #microglia #astrocytes biology! We have some exciting new #NIH funded #coolprojects and we'd love a new, enthusiastic team member! If interested DM me

Li-Juan Duan et al. show that #Tailless (TLX) and #hypoxia inducible factor-2α (HIF2α) cooperate to sustain proangiogenic states of retinal #astrocytes in neonatal mice:

https://journals.biologists.com/bio/article/12/1/bio059684/286421/Tailless-and-hypoxia-inducible-factor-2-cooperate

#Retina #Angiogenesis #OxygenSensing #Science #BiologyOpen #Biology #AcademicMastodon

I can't get enough of these 🐭 cells (green, neural stem cells and #astrocytes) engrafted in the #zebrafish 🧠 and incorporating and maybe synapsing? #FluorescenceFriday

Open Science #OpenScience #OpenData #neuroscience #astrocytes #zebrafish

We published whole-brain neuron+glia light-sheet calcium imaging data...

... from Mu et al., Cell 2019, 12 fish, 5.9 TB, >1,000,000 cells total + behavior, NWB format

Data: https://dandiarchive.org/dandiset/000350

Paper: https://www.cell.com/cell/fulltext/S0092-8674(19)30621-X

Thank you CatalystNeuro + authors for implementing, and
Simons Foundation Global Brain for supporting this effort!

Data is open for everyone to use. We are also happy to actively collaborate!

RT @DeRubeisLab@twitter.com

So excited to resume our @SeaverAutism@twitter.com series 🤩💪🏽

Can't wait to host Cagla Eroglu (@c_eroglu@twitter.com) on 1/11 11AM to learn how #astrocytes sculpt synaptic circuits 🧠🧫🔬

Join us on @worldwideneuro@twitter.com 👇🏽
https://www.world-wide.org/seminar/8674/

@MountSinaiPsych@twitter.com @SinaiBrain@twitter.com @DukeNeuro@twitter.com @DukeCellBiology@twitter.com https://twitter.com/DeRubeisLab/status/1608551749593489408

🐦🔗: https://twitter.com/DeRubeisLab/status/1609992543697047559

#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)

#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)

📢 New preprint out ! 📢
We investigate how and why the disruption of the astrocyte network (through the KO of gap junctions) affects the neuronal bursting phenotype.
Combining experiments and a new mathematical model based on synaptic short-term plasticity we found that the main affected mechanism is afterhyperpolarization through KCNQ channels regulation !

https://www.biorxiv.org/content/10.1101/2022.12.14.520502v1

#astrocytes #glia #neuroscience #modeling #dynamicalSystems #afterhyperpolarization

#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial #pannexin 1 channels *inhibits* hippocampal #neuronal networks - a novel negative feedback loop #PLOSBiology https://plos.io/3h65tXQ

#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial #pannexin 1 channels *inhibits* hippocampal #neuronal networks - a novel negative feedback loop #PLOSBiology https://plos.io/3h65tXQ