How to use your neighbours to get ahead: #glioblastoma cells use #ExtracellularVesicles to encourage neighbouring #astrocytes to secrete pro-invasive #ECM components.
#preLight from Jade Chan covering work led by Dominik Koessinger #CRUK_BI
#glioblastoma #extracellularvesicles #Astrocytes #ECM #prelight #cruk_bi #cancerbiology
RT @maglarecherche
Pour tout comprendre de ce travail de @EleonoreHardy_ et @RancillacA qui caractérise l'impact de l'expression d'une protéine exprimée par les #astrocytes sur l'activité neuronale et ouvre des perspectives thérapeutiques. @PLOSBiology
https://www.larecherche.fr/neurosciences-cerveau/la-taille-du-r%C3%A9seau-astrocytaire-est-d%C3%A9terminante-pour-l%E2%80%99activit%C3%A9-neuronale
Upregulation of #connexin 30 in #astrocytes increases connectivity of #astroglial networks, but decreases synaptic transmission, altering #SynapticPlasticity & learning processes @EleonoreHardy_ @NathalieRouach @RancillacA &co #PLOSBiology https://plos.io/3UrHRMx
#plosbiology #synapticPlasticity #astroglial #Astrocytes #connexin
Upregulation of #connexin 30 in #astrocytes increases connectivity of #astroglial networks, but decreases synaptic transmission, altering #SynapticPlasticity & learning processes @EleonoreHardy_ @NathalieRouach @RancillacA &co #PLOSBiology https://plos.io/3UrHRMx
#plosbiology #synapticPlasticity #astroglial #Astrocytes #connexin
Further studies are needed to understand their full contribution to neurodegeneration. #neurodegenerative #astrocytes
#neurodegenerative #Astrocytes
RT @SRBR_Outreach
Are #astrocytes under-appreciated in their role in brain function and circadian rhythms? This @AnnualReviews Neuroscience by Hastings, @MarcoBrancacci4, Gonzalez-Aponte and @ErikHerzog seeks to redress the balance:
https://www.annualreviews.org/doi/abs/10.1146/annurev-neuro-100322-112249
Are #astrocytes under-appreciated in their role in brain function and circadian rhythms? This @AnnualReviews Neuroscience by Hastings, @MarcoBrancacci4, Gonzalez-Aponte and @ErikHerzog seeks to redress the balance:
https://www.annualreviews.org/doi/abs/10.1146/annurev-neuro-100322-112249
@PhiloNeuroScie Wow, linking neuromodulation with glia and the synchrony of neuronal activity. How interesting. It's giving me ideas for experiments to run in #Drosophila to study the contributions of astrocyte-like glial cells.
#glia #Astrocytes #neuroscience #drosophila
RT @sadagurski
@sadagurski's lab is HIRING!! We are looking for a talented #postdoc interested in the hypothalamic regulation of metabolism, and #microglia #astrocytes biology! We have some exciting new #NIH funded #coolprojects and we'd love a new, enthusiastic team member! If interested DM me
#postdoc #Microglia #Astrocytes #nih #coolprojects
Li-Juan Duan et al. show that #Tailless (TLX) and #hypoxia inducible factor-2α (HIF2α) cooperate to sustain proangiogenic states of retinal #astrocytes in neonatal mice:
#Retina #Angiogenesis #OxygenSensing #Science #BiologyOpen #Biology #AcademicMastodon
#tailless #Hypoxia #Astrocytes #retina #angiogenesis #oxygensensing #Science #biologyopen #biology #AcademicMastodon
I can't get enough of these 🐭 cells (green, neural stem cells and #astrocytes) engrafted in the #zebrafish 🧠 and incorporating and maybe synapsing? #FluorescenceFriday
#Astrocytes #zebrafish #fluorescenceFriday
Open Science #OpenScience #OpenData #neuroscience #astrocytes #zebrafish
We published whole-brain neuron+glia light-sheet calcium imaging data...
... from Mu et al., Cell 2019, 12 fish, 5.9 TB, >1,000,000 cells total + behavior, NWB format
Data: https://dandiarchive.org/dandiset/000350
Paper: https://www.cell.com/cell/fulltext/S0092-8674(19)30621-X
Thank you CatalystNeuro + authors for implementing, and
Simons Foundation Global Brain for supporting this effort!
Data is open for everyone to use. We are also happy to actively collaborate!
#openscience #opendata #neuroscience #Astrocytes #zebrafish
RT @DeRubeisLab@twitter.com
So excited to resume our @SeaverAutism@twitter.com series 🤩💪🏽
Can't wait to host Cagla Eroglu (@c_eroglu@twitter.com) on 1/11 11AM to learn how #astrocytes sculpt synaptic circuits 🧠🧫🔬
Join us on @worldwideneuro@twitter.com 👇🏽
https://www.world-wide.org/seminar/8674/
@MountSinaiPsych@twitter.com @SinaiBrain@twitter.com @DukeNeuro@twitter.com @DukeCellBiology@twitter.com https://twitter.com/DeRubeisLab/status/1608551749593489408
🐦🔗: https://twitter.com/DeRubeisLab/status/1609992543697047559
#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)
#ascendingvenules #penetratingarterioles #endfeet #astrocytesoma #bloodvessels #parenchymal #Astrocytes
#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)
#ascendingvenules #penetratingarterioles #endfeet #astrocytesoma #bloodvessels #parenchymal #Astrocytes
📢 New preprint out ! 📢
We investigate how and why the disruption of the astrocyte network (through the KO of gap junctions) affects the neuronal bursting phenotype.
Combining experiments and a new mathematical model based on synaptic short-term plasticity we found that the main affected mechanism is afterhyperpolarization through KCNQ channels regulation !
https://www.biorxiv.org/content/10.1101/2022.12.14.520502v1
#astrocytes #glia #neuroscience #modeling #dynamicalSystems #afterhyperpolarization
#afterhyperpolarization #dynamicalSystems #modeling #neuroscience #glia #Astrocytes
#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial #pannexin 1 channels *inhibits* hippocampal #neuronal networks - a novel negative feedback loop #PLOSBiology https://plos.io/3h65tXQ
#plosbiology #neuronal #pannexin #Astrocytes
#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial #pannexin 1 channels *inhibits* hippocampal #neuronal networks - a novel negative feedback loop #PLOSBiology https://plos.io/3h65tXQ
#plosbiology #neuronal #pannexin #Astrocytes