#IDMastodon #publichealth #Viralimmunology Understanding why we have different responses & symptoms to #SARSCoV2 ( #COVID19) & #influenza 🦠. What these 2 diseases have in common is that they are triggered by a viral infection, which causes fever & pneumonia of varying degrees of severity in infected patients. #Autoantibodies against #interferons, or why certain 🦠 affect us differently
https://rupress.org/jem/article/220/9/e20230661/214186/Autoantibodies-neutralizing-type-I-IFNs-underlie

#IDMastodon #thombosis @scireports
#COVID19 severity linked to #Autoantibodies against blood clotting protein . Considering VWF, ADAMTS13 activity, & ADAMTS13 autoantibodies levels during the diagnostic workup of #COVID19 may also provide important insights into disease severity.
📌 https://www.nature.com/articles/s41598-023-37405-5
📌 https://www.news-medical.net/news/20230702/COVID-19-severity-linked-to-autoantibodies-against-blood-clotting-protein.aspx

#IDMastodon
#Viralimmunology #Immunology @casanova_lab et al Grat paper on Interfering with #interferons A Critical Mechanism for critical #COVID19 . Genetic studies in patients have established that critical cases can re- sult from inborn errors of TLR3- or TLR7-dependent type I interferon immunity, or from preexisting #autoantibodies neutralizing primarily IFN-α and/or IFN-ω.
https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-101921-050835

#IDMastodon #mucosalimmunity #Immunology @BenHalePhD Excellent #Clinicalreviews #Autoantibodies targeting type I interferons: Prevalence, mechanisms of induction & association with viral disease susceptibility ,severe #COVID19 , influenza, or herpes (varicella-zoster virus, herpes simplex virus, cytomegalovirus )
📌 https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202250164
📌 https://pubmed.ncbi.nlm.nih.gov/37027328/
📌 https://onlinelibrary.wiley.com/toc/15214141/0/ja

#IDMastodon #PedsID @panhammarstrom @casanova_lab There is growing evidence to suggest that severe disease in children infected with common viruses or #SARSCoV2 that are benign in other children can result from inborn errors of immunity or their phenocopies. #COVID19 can lead to acute #hypoxemic in children with inborn errors of type I ( IFN) immunity or #Autoantibodies against IFNs.
📌 https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.13628
📌 https://pubmed.ncbi.nlm.nih.gov/36906905/

#IDMastodon @Nature #Immunology of #COVID19
#Autoantibodies against chemokines post#SarsCoV2 infection correlate with disease course
📌 https://www.nature.com/articles/s41590-023-01445-w
📌 https://www.nature.com/ni/volumes/24/issues/3
📌https://www.nature.com/collections/aeacbbicec
📌 https://www.nature.com/search?q=Presence+of+Specific+Antibodies+Could+Be+Protective+against+Long+COVID&journal=

#IDMatodon @JCI_insight @StanfordMed These #clinicalreview demonstrate that anti-cytokine and #autoantibodies are common across different viral including #SARSCoV2 and nonviral infections and range in severity of illness.
📌 https://insight.jci.org/articles/view/163150?utm_content=buffer1d797&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

🔥@ Front. Immunol | #Autoantibodies as #biomarkers for breast cancer #diagnosis and prognosis: Breast cancer is the most common #cancer in #women worldwide and is a substantial public health problem. Screening for #breastcancer mainly relies on mammography, which leads to false positives and missed diagnoses and is especially non-sensitive for patients with small tumors and dense breasts. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035402/full
#immunology