Creating loss-of-function mutations with cytidine base editors (CBE). Our new preprint is online. Work of the incredible Roman Doll (part! of his master thesis).

#CRISPR #geneediting #baseediting #Drosophila #CFDbaseedit

We set up a very efficient system to install premature stop codons or disrupt splice sites in Drosophila and made some interesting discoveries along the way. Will unpack these in separate threads in the coming days. For now here is the manuscript:

https://www.biorxiv.org/content/10.1101/2022.12.13.520203v1

Base editing: Revolutionary therapy clears girl's incurable cancer https://www.bbc.com/news/health-63859184 #BaseEditing #cancertherapies

BBC News - #BaseEditing: Revolutionary therapy clears girl's incurable #cancer
https://www.bbc.co.uk/news/health-63859184

Wow. Das wird in den nächsten Jahren einiges verändern und gibt Hoffnung für die Heilung von weiteren Krankheitten. #medizin #BaseEditing #Krebs https://www.bbc.com/news/health-63859184

A great opportunity to join the lab of a stellar early-career scientist who continues to illuminate the molecular workings of gene editing agents. Plus, lots of sun there☀️

RT @Sarkele1@twitter.com

🚨We are hiring!🚨

The Lapinaite Lab is looking for a Postdoctoral Fellow #postdocposition with experience in #CryoEM. Join us and be part of an international team of researchers studying #CRISPR #baseediting #precisionmedicine #RNA

How to apply:
https://www.lapinaitelab.org/open-positions

🐦🔗: https://twitter.com/Sarkele1/status/1593000873923604480

RT @jcornlab@twitter.com

#FanconiAnemia causes devastating bone marrow failure. But #CRISPR HDR editing doesn't work in cells from these patients. In collaboration w/ @PauFerrol@twitter.com & funding @EJPRareDiseases@twitter.com we develop a #BaseEditing approach for bone marrow cells from FA patients. https://www.nature.com/articles/s41467-022-34479-z

🐦🔗: https://twitter.com/jcornlab/status/1592178188733812737