#IDMastodon #Immunology These results demonstrate that serial #Covid19vaccination strategies can be effective for a subset of #Bcell–depleted patients. While #Bcell depletion is associated with attenuated antibody responses to #SARSCoV2. #COVID19 Vaccination responses vary among individuals.
https://insight.jci.org/articles/view/168102?utm_content=buffer33a64&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

@florian_krammer @vivianasimonlab #hybridimmunity showed better protection against breakthrough infection in both the pre-Omicron but also the post-#Omicron era & the breakthrough infections in vaccinated, previously naïve individuals have an effect like a booster dose.These data suggest that #COVID19 mRNA vaccination does induce long lasting spike-specific antibodies consistent w #Bcell #biology
https://www.medrxiv.org/content/10.1101/2023.08.26.23294679v1.full.pdf

In immunological research on #SarsCoV2 the relationship between specific IgG titer and memory recall response has not been fully investigated .Recently shown substantial IgG4-switched, spike-binding memory #Bcell populations following mRNA vaccination .#COVID19vaccines induce high proportion of spike-specific IgG4 antibody responses in the individual who previously not been infected with #SARSCOV2 🦠 .

Local enhancers of the #PAIR4 regulatory module promote distal V-H gene #recombination at the #Igh locus and contribute to #Bcell receptor repertoire diversification

Louisa Hil et al Busslinger lab @IMPvienna

https://www.embopress.org/doi/full/10.15252/embj.2022112741

#Immunology #idmastodon #Cellimmunity @Nature #SARSCoV2 #booster #immunizations in humans induce robust GC B cell responses & can generate de novo #Bcell responses targeting #Omicron sub-variant-specific epitopes.
📌 https://www.nature.com/articles/s41586-023-06025-4_reference.pdf
📌 https://www.nature.com/articles/s41467-023-37432-w
📌 https://www.nature.com/search?q=Covid19&order=relevance&date_range=2022-2023

EMBO Journal Issue 4/23:
- Commentary on #creativity needs in research
- #Degron recognition in orphan complex subunits by CLR4-DCAF12 E3 #ubiquitin #ligase
- #Plasmamembrane topography of #IgM #Bcell receptors
- #YAP roles and regulation in #tumorigenesis
- #Brassinosteroid interplay with #katanin #microtubule severing

Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
https://www.embopress.org/toc/14602075/2023/42/4

An Immunological Review of SARS-CoV-2 Infection and Vaccine Serology: Innate and Adaptive Responses to mRNA, Adenovirus, Inactivated and Protein Subunit Vaccines
#COVID19 #vaccines #Pfizer #BioNTech #Oxford #AstraZeneca #Sinopharm #Novavax #antibody_response #Tcell #Bcell #neutralizing_antibodies #adaptive #immune #response #immunology
https://www.mdpi.com/2076-393X/11/1/51

“Spacing the first two doses of #SARSCoV2 #mRNA #vaccines beyond 3–4 weeks raised initial concerns about vaccine efficacy. ..studies have since shown that long-interval regimens induce robust antibody responses, .. we compare SARS-CoV-2 naive donors #Bcell and #Tcell responses to two mRNA vaccine doses administered 3–4 versus 16 weeks apart. After boost, the longer interval results in a higher magnitude and a more mature phenotype of RBD-specific B cells.”

https://www.cell.com/iscience/fulltext/S2589-0042(22)02177-0?rss=yes&utm_source=dlvr.it&utm_medium=twitter

#IDMastodon #Immunology #Clinicalperspective @ScienceMagazine A vaccine sanctuary in the lymph node .#Bcell follicles in the lymph node protect vaccines to enhance immune responses
📌 https://www.science.org/doi/epdf/10.1126/science.adf5134
📌 https://www.science.org/doi/epdf/10.1126/science.abn8934

more #immunology opinions by Brian Laidlaw on #Bcell memory
https://www.sciencedirect.com/science/article/abs/pii/S0952791522001285

#Bcell - #Tcell collaboration in the lung, @wadschma & @dpschreiner @unibasel
https://www.sciencedirect.com/science/article/pii/S0952791523000031

next up to read: really interesting new work by @marionpepper lab

already thinking how we might integrate this into what we learned from Gaya/Milpied labs showing IL4 promotes more permissive GC and "bystander" memory B cells in the tissue

IL-4 downregulates BCL6 to promote memory #Bcell selection in germinal centers | bioRxiv

https://www.biorxiv.org/content/10.1101/2023.01.26.525749v1

#Plasmamembrane topography governs the 3D dynamic localization of #IgM #Bcell #antigenreceptor clusters

Deniz Saltukoglu, Michael Reth et al at University Freiburg use high-resolution #microscopy on the #Burkitt’s Lymphoma model Ramos B-cell line to reveal surface topographical features facilitating screening of #antigens

https://www.embopress.org/doi/10.15252/embj.2022112030

New from Prof. Shane Crotty and Yu Kato at LJI and Andrew G Letizia at the Naval Medical Research Center:

"Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection" https://doi.org/10.1093/infdis/jiac319

Read for a close look at spike #antibody titers, pseudovirus neutralizing antibody titers, and memory #Bcell responses among #SARSCoV2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. #OpenAccess #COVID19 #immunology #InfectiousDisease

RT @DrFAlzaid@twitter.com

Latest curated articles👇🏽
📰PD1 deletion destabilizes lineage identity & metabolic fitness of tumor-infiltrating #TRegs (📷)
📰#SREBP is essential for #Bcell responses
🧠Mouse brain aging single cell molecular & spatial signatures
🔗http://biomed.news/bims-nimamd/2023-01-01
🙏🏽Thx @Bims_BiomedNews@twitter.com

🐦🔗: https://twitter.com/DrFAlzaid/status/1609649287515803649

RT @Lo_Zanzi@twitter.com

#SameSameButDifferent! The SERBP pathway in #Bcell is more than “just” cholesterol control! It regulates mTORC1 impacting cell cycle & energy metabolism! SERBP signaling controls #GerminalCenter formation & responses to #vaccine or #viruses! @NatImmunol@twitter.com http://doi.org/10.1038/s41590-022-01376-y

🐦🔗: https://twitter.com/Lo_Zanzi/status/1608525722930352130

Thanks to great work from
Pam Rosato, Hanna Degefu and Tyler Searles, we've updated our #biorxiv preprint led by Kristin Fitzpatrick describing the development and use of an easy and robust bead-based approach to validate and monitor ligand tetramer performance for detection of antigen-specific lymphocytes by #flowcytometry. #antigenspecific #Tcell #Bcell https://www.biorxiv.org/content/10.1101/2022.10.24.513230v2

@SalinasLab has a cool paper describing nasal associated lymphoid tissue (NALT) as a site for #Bcell and #Tcell #immune responses in fish #mucosalimmunity #evolution https://doi.org/10.4049/jimmunol.2200396

Referenced link: https://phys.org/news/2022-10-3d-molecular-igm-type-cell-antigen.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-10-3d-molecular-igm-type-cell-antigen.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1582753456015933441#m

Researchers map the 3D molecular structure of an IgM-type #Bcell antigen receptor @UniFreiburg @nature https://www.nature.com/articles/s41586-022-05412-7 https://phys.org/news/2022-10-3d-molecular-igm-type-cell-antigen.html