#IDMastodon #Neuroimmunology #Neurocovid @frontimmunol
Compelling evidence for a causal effect of #COVID19 phenotype on AQP4+ NMOSD, shedding new light on the understanding of the comorbidity between #COVID19 & #neuromyelitisopticaspectrumdisorder . The underlying pathogenesis is that #SARSCoV2 infection of multiple cells, macrophages, neutrophils & dendritic cells, induces an #immuneresponse in #Tcells & #Bcells

Referenced link: https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1668251600500973571#m

RT by @physorg_com: Macrophages that rapidly digest dying #Bcells may point to future autoimmune disorder treatments @JExpMed https://rupress.org/jem/article/220/4/e20222173/213834/Tingible-body-macrophages-arise-from-lymph-node https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html

Referenced link: https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666852164860358661#m

RT by @physorg_com: Study uncovers how #Bcells react to skin cancer @kingscollegelon @NatureComms https://www.nature.com/articles/s41467-023-39042-y https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html

📢 New review on the functions of double-negative #Bcells in #AutoimmuneDiseases, #infections, and #cancers

By N-W Kam, W Dai & colleagues at University of Hong Kong

🗞️ Read #openaccess: https://doi.org/10.15252/emmm.202217341

#IDMastodon #immunology @JExpMed
understanding Inborn errors of human B cell development, differentiation & function. #Bcells develop from hematopoietic stem cells in the bone marrow. Once generated, they serve multiple roles in immune regulation and host defense. However, their most important function is producing Ab that efficiently clear invading pathogens.
https://rupress.org/jem/article/220/7/e20221105/214141/Inborn-errors-of-human-B-cell-development

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

important new work by @KhaderShabaana lab highlighting the impact of #Bcells during #Tuberculosis. best of all - they are crucial players in protection after vaccination/challenge! https://rdcu.be/c83ty

@vdumeaux @cyrilpedia @gpollara Which brings on the #immunology in #oncology story of tertiary lymphoid structures #tls TLS and their role in anti-tumor #immunity ...from #lymphocytes to antigen-presenting #Bcells and #Immunotherapy responses. https://pubmed.ncbi.nlm.nih.gov/31942075/

excited to see this one by Carl Feng &colleagues: https://doi.org/10.1084/jem.20221392 #Tuberculosis #spatial #Bcells

#Cancerimmunotherapies #DrugDevelopment @cellpress
Understanding Role of #Bcells in the #tumormicroenvironment Multi-faceted organizers, regulators, and effectors of anti-#TumorImmunity
📌 https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00045-4?rss=yes&utm_source=dlvr.it&utm_medium=twitter
📌 https://www.cell.com/cancer-cell/issue?pii=S1535-6108(22)X0006-8

The one and only @Alhkim lecturing our #rheumfellows on his second favorite topic (#sle will always be #1), #BCells! 🔬

#Immunology #Rheumatology #MedEd #MDPhD #Scientist

https://www.news-medical.net/news/20230201/New-study-suggests-Omicron-BA1-breakthrough-infection-drives-long-term-remodeling-of-memory-B-cell-repertoire-in-vaccinated-populations.aspx
#BA1
think these studies are all supposed to be “comforting & reassuring” but having had #sarscov2 1.0 aka🇨🇳via🇮🇹then 2 #Pfizer & then BA.1…

trust my remodeled #bCells as much as I trust my psychopath 1/2 brother🙄,which is to say, negative quadrillion

BA.1 drove me into 24/7 obsession w/ #reinfection & all things #Covid

& after nearly catching BA.5 imo it’s either avoid like the Plague it is or suffer lifelong consequences
We need updated & better #vaccines #Novavax 💉💉💉💉

#Innate and #Adaptive #Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms
#COVID19 #Bcells #neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SARSCoV2
https://www.mdpi.com/2076-393X/11/2/408

#Bcells in human lymphoid structures | Clinical and Experimental Immunology | Oxford Academic

https://academic.oup.com/cei/advance-article/doi/10.1093/cei/uxac101/6825355

@gpollara @ImmunityCP but no #Bcells 😢

@Nature @cellpress @biorxivpreprint
Maturation of #SarsCoV2 Spike-specific memory #Bcells drives resilience to viral escape
📌 https://www.sciencedirect.com/science/article/pii/S258900422201999X
📌 https://www.biorxiv.org/content/10.1101/2023.01.03.519511v1.full.pdf

https://nitter.pussthecat.org/tactnowinfo/status/1611185494326497282?s=46
#virus #fungi #bacteria #tcells #lymphocytes #bcells #cancer #hiv #xbb15
Tbh I’m not sure I’d be able to convince 90% of the population that is already checked out & in complete denial..

I just post for those people who are still trying & wondering if they should just give up🖤

#dontGiveUp #DontInhaleTheVirus #viralDose #HEPA #keepMasking #CovidPapers #LongCovid

sometimes it's really great to have all the major points in one source. this is a comprehensive review on #immune cells and #Tuberculosis by @joanneflynn19 and John Chan; and of course there is also a great section highlighting what we know (& mostly don't know) about #Bcells
https://www.cell.com/cell/fulltext/S0092-8674(22)01371-X

“Even though they constitute a small fraction of the total number of cells later on, the founder cells that stay in the germinal center for a long time are still doing their job,"
"But just how well those founder B cells do their jobs, and whether naïve recruits cramp their style and reduce their efficacy, remains to be seen." #germinalcenters #bcells #respiratoryviruses

https://www.genengnews.com/topics/translational-medicine/germinal-center-insights-can-lead-to-better-understanding-of-immunity/?MailingID=%DEPLOYMENTID%&utm_medium=newsletter&utm_source=GEN+Daily+News+Highlights&utm_content=01&utm_campaign=GEN+Daily+News+Highlights_20221228&oly_enc_id=6688E2244356C6Z

RT @BcellBruno@twitter.com

We are so excited that an IN-PERSON conference completely focused on B cells and TLS will be happening next year! Mark your calendars and thanks to @KeystoneSymp@twitter.com for this opportunity! #Bcells #TLS @hollern_daniel@twitter.com

🐦🔗: https://twitter.com/BcellBruno/status/1605659166831480871