"This study examined the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment."

#Preprint #Neuroimmunology #BloodBrainBarrier #Immunology #Infection #InfectiousDisease

https://www.biorxiv.org/content/10.1101/2023.01.23.524949v1

Tools

"Here we incorporated inside EVs the endogenous retrovirus-like Arc protein capsids, stabilized by Arc 5'UTR RNA elements, to effectively load and deliver mRNAs. Produced from self-derived leukocytes, engineered retrotransposon Arc EVs (eraEVs) are immunologically inert with minimal clearance. Equipped with endothelial adhesion molecules from donor leukocytes, circulating eraEVs enter the brain enriching at neuro-inflammatory sites. "

#Preprint #Neuroscience #BloodBrainBarrier

https://www.biorxiv.org/content/10.1101/2022.12.07.518870v2

Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer’s, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer’s brain.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Alzheimer #Brain #BBB #BloodBrainBarrier #Insulin #InsulinResistance

https://neurosciencenews.com/insulin-resistance-alzheimers-22104/

3D hydrogel #BloodBrainBarrier model (EC+SMC+Astrocyte, ɸ 600 µm)
+Defined, zonated flow profiles

Transcriptomics of #EndothelialCell with Disturbed vs Laminar flow for 24 h->
#Lumican in #VascularPermability

Dr. Peter Galie lab Fluids Barriers CNS 2022
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-022-00389-x

Gene-Delivering Viruses Reach the Brain in Step Towards Gene Therapy of Neurological Diseases
Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegerativeDiseases #Brain #BloodBrainBarrier #GeneTherapy #ViralVector #AAV

https://neurosciencenews.com/avvs-bbb-21921/

Editing a gateway for #CellTherapy across #BloodBrainBarrier

An excellent review🤠 Learn a lot!

Lesson from Leukocyte-#BBB interaction->
Engineering strategies->
⏫Cell delivery to injured🧠#Stroke

#openaccess

Dr. Rust Ruslan lab Brain 2022
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac393/6832391