Exploitation of host cell #organelles by an intracellular #pathogen: #Brucella abortus not only uses the ER to replicate, but later also localizes to and fragments #mitochondria to aid bacterial egress via #mitophagy
Thierry Arnould et al
https://www.embopress.org/doi/10.15252/embj.2022112817

Great collaborative effort with the Laurent Terradot team on two new #Brucella effectors modulating nuclear proteins just published in Nature Communications. Massive work by outstanding young scientists Arthur Louche and Amandine Blanco who combined #StructuralBiology, #InfectionBiology and a bit of mythology for naming the proteins, and ended up with a lot more questions than when we started!
Congrats to all involved
#Microbiology #Bacterial #Pathogenesis
https://www.nature.com/articles/s41467-022-35763-8

Second try!
#Science #Introduction
Based in beautiful #Lyon #France we study #bacterial #pathogens

Our focus: the intracellular sneaky pathogen #Brucella abortus; and the multi-drug resistant (not so sneaky) #Acinetobacter baumannii.

We want to know how they interact with cells, how they hide inside and what they inject into them to make all this happen.

This is our lab account, an international, inclusive, fun team with #microbiology, #InfectionBiology and #biochemistry expertise