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Tom Kindlon · @tomkindlon
777 followers · 2079 posts · Server disabled.social

Induces & Suppresses Peroxisomes in the Brain

shorturl.at/dhmrZ

“The present studies point to a role of persistent neuroinflammation, especially inflammasome activation, and peroxisome biogenesis factor suppression as contributing determinants of the neurological sequelae of -19”

@longcovid @covid @covid19 @novid

#COVID19 #neuroinflammation #covid #LongCovid #pwlc #postcovidsyndrome #lc #PostCovid #COVID_19 #sarscov2 #novid #CovidIsNotOver

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
777 followers · 2078 posts · Server disabled.social

New from Italy
Structural & functional impairments of skeletal muscle in patients with post-acute sequelae of infection

shorturl.at/csvyX

“In our cohort of patients with , we showed limited exercise tolerance mainly due to ‘peripheral’ determinants. Substantial reductions were observed for biomarkers of mitochondrial function, content, & biogenesis”

@longcovid @covid @covid19

#sarscov2 #PASC #LongCovid #pwlc #lc #PostCovid #covidー19 #COVID19 #covid #COVID_19

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
777 followers · 2078 posts · Server disabled.social

2/

“Fecal transplantation from subjects to germ-free mice led to lung inflammation & worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of infection on the gut microbiota that persist after subjects have cleared the virus”

@longcovid
@covid

#PostCovid #sarscov2 #LongCovid #pwlc #postcovidsyndrome #lc #covidー19 #COVID19 #covid #COVID_19

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
777 followers · 2076 posts · Server disabled.social

Gut microbiota from patients with cause alterations in mice that resemble post- symptoms

shorturl.at/ipuvH

“we report the gut microbiota of subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces”

@longcovid
@covid19

1/

#COVID19 #covid #PostCovid #LongCovid #pwlc #covidー19 #COVID_19 #sarscov2 #novid #lc

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
777 followers · 2075 posts · Server disabled.social

reservoir in post-acute sequelae of (). Review by 33 authors

shorturl.at/knoUX

“we explore evidence for SARS-CoV-2 reservoir in PASC & provide context on interpretation of the findings. We delineate mechanisms by which a SARS-CoV-2 reservoir may contribute to PASC pathology & identify central research priorities & methods to guide the continued study of SARSCoV2 persistence in PASC”

@longcovid

#sarscov2 #COVID19 #PASC #LongCovid #pwlc #PostCovid #covidー19 #covid #COVID_19 #lc

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
774 followers · 2033 posts · Server disabled.social

“Trial By Error: Call for Retraction of Cochrane Review from Science For ME; Overview of Viral Persistence in Long ; (US) Senators United on ” by David Tuller DrPH (September 7)

surl.li/kxbew

@mecfs  @longcovid
@covid @covid19

#covid #LongCovid #mecfs #cfs #myalgice #pwme #MyalgicEncephalomyelitis #chronicfatiguesyndrome #pwlc #postcovidsyndrome #PostCovid #covidー19 #COVID19 #COVID_19 #sarscov2

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
768 followers · 1998 posts · Server disabled.social

Prevalence and Risk Factors of de Novo Widespread Post- Pain in Non-Hospitalized COVID-19 Survivors: A Nation-Wide Exploratory Population-Based Survey

rb.gy/mrmg5

“de novo [=new] widespread was present in 5.3% of non-hospitalized COVID-19 survivors one year after infection (14.4±6.0 months)”

@longcovid
@covid @covid19
@novid

#covid #PostCovid #pain #LongCovid #pwlc #postcovidsyndrome #covidー19 #COVID19 #COVID_19 #sarscov2 #novid #CovidIsNotOver

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
766 followers · 1995 posts · Server disabled.social

Retrospective study of experiences in elite multinational aquatic athletes

rb.gy/sxndx

“The majority reported mild (51%) or moderate (27%) symptoms, while 16% remained asymptomatic. Reinfection occurred in 13%, and 10% of initial infections led to with fatigue (65%) & shortness of breath (48%) being the most common long-term symptoms”

@longcovid
@covid
@novid

#COVID19 #LongCovid #pwlc #PostCovid #covidー19 #covid #COVID_19 #sarscov2 #novid #CovidIsNotOver

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
766 followers · 1995 posts · Server disabled.social

Gray Matter Changes Following Mild An MR Morphometric Study in Healthy Young People

rb.gy/8e24x

“Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume”

@longcovid
@covid @covid19
@novid

#COVID19 #LongCovid #pwlc #PostCovid #covidー19 #covid #COVID_19 #sarscov2 #novid #CovidIsNotOver

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
765 followers · 1992 posts · Server disabled.social

spike protein induces endothelial inflammation via ACE2 independently of viral replication

“Here we demonstrate SARS-CoV-2 is a potent inducer of pro-inflammatory molecules, such as cytokines (IL-6, TNFα), chemokines (MCP-1), PAI-1 and adhesion molecules (ICAM-1, VCAM-1), and that it activates pro-inflammatory signalling through NFκB and ERK1/2 in endothelial cells.”

rb.gy/bu5k2

@longcovid

#sarscov2 #LongCovid #pwlc #PostCovid #covidー19 #COVID19 #covid #COVID_19

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
765 followers · 1992 posts · Server disabled.social

The autonomic syndrome in hospitalized patients

“In a group of hospitalized patients with severe the overall autonomic symptoms measured by COMPASS-31 score followed a bi-phasic pattern over time. Symptoms worsened during the acute phase, improved from 1 to 3 months post-discharge, but aggravated at 6 and 12 months.”

rb.gy/kolnu

@longcovid @covid @covid19

#LongCovid #sarscov2 #pwlc #PostCovid #covidー19 #COVID19 #covid #COVID_19 #novid #CovidIsNotOver

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
763 followers · 1976 posts · Server disabled.social
Open media

"It's likely you know someone dealing with long COVID"

Excellent 24-minute, August 30 audio interview on NPR with science journalist @edyong209 & co-founder of the Patient-Led Research Collaborative and /ME sufferer

A lot about ME/CFS

npr.org/podcasts/1137012696/th

Also:
wbez.org/stories/the-rundown-w

@longcovid
@covid @covid19
NoVID@chirp.social @mecfs

#LongCovid #pwlc #postcovidsyndrome #PostCovid #covidー19 #COVID19 #covid #COVID_19 #sarscov2 #novid #MyalgicEncephalomyelitis #mecfs #cfs #pwme #myalgice

Last updated 1 year ago
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Professor Lyla Mehta · @Lylamehta
533 followers · 362 posts · Server mas.to

School closures announced in the UK just before term starts. The govt ditched years ago despite warnings.

They have done the same about protecting kids from an airborne virus & .

is clearly structural but so much more, incl. (ventilation).

bbc.com/news/education-6668170

#cleanair #COVID_19 #schoolsafety

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
756 followers · 1948 posts · Server disabled.social

(From March)
Canada’s Minister of Health, announced a $20 million investment from the Canadian Institutes of Health Research (CIHR) to support a pan-Canadian Post COVID-19 Condition Research Network called Long COVID Web

canada.ca/en/public-health/new

@longcovid

@covid @covid19

#LongCovid #pwlc #postcovidsyndrome #PostCovid #PostCovid19 #lc #covidlonghaulers #LongHaulers #covidー19 #COVID19 #covid #COVID_19 #sarscov2

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
755 followers · 1944 posts · Server disabled.social

3/

There are risks to the individual (the risk of death, but also the risk of long term health issues and even the risk of not being able to earn money or carry out other activities when ill). There also risks to people they are in contact with.

@covid @covid19
@longcovid

#LongCovid #pwlc #postcovidsyndrome #PostCovid #PostCovid19 #lc #covidlonghaulers #LongHaulers #covidー19 #COVID19 #covid #COVID_19 #sarscov2

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
755 followers · 1943 posts · Server disabled.social

2/

Her message is that journalists are treating the pandemic as if Covid infections don’t matter any more and it’s time to move on. This, she says, shames people who remain cautious about Covid and it does not communicate the risks which still exist.

@covid @covid19 @longcovid

#LongCovid #pwlc #postcovidsyndrome #PostCovid #PostCovid19 #lc #covidlonghaulers #LongHaulers #covidー19 #COVID19 #covid #COVID_19 #sarscov2 #mask

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
751 followers · 1917 posts · Server disabled.social

2/

“Taken together the findings suggest that the risk horizon for postacute sequelae after infection is prolonged even among nonhospitalized individuals and is further prolonged among hospitalized individuals—highlighting the importance of reducing risk of hospitalization among people with SARS-CoV-2 infection (and reinfection) as a means to reduce the risk of long-term health loss.”

@longcovid @covid @covid19

#sarscov2 #LongCovid #pwlc #postcovidsyndrome #covidー19 #COVID19 #covid #COVID_19

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
751 followers · 1913 posts · Server disabled.social
Open media

#LongCovid #pwlc #postcovidsyndrome #PostCovid #PostCovid19 #lc #covidlonghaulers #LongHaulers #covidー19 #COVID19 #covid #COVID_19

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
749 followers · 1910 posts · Server disabled.social

Incidence of long and associated psychosocial characteristics in a large U.S. city

tinyurl.com/4nvva6ae

“Residual effects of are very common and nearly one-fifth of our sample met the most restrictive definition of warranting concern as a public health issue”

@covid @covid19 @longcovid

#covid #COVID19 #LongCovid #longcovid19 #COVID_19 #PostCovid19 #postcovidsyndrome #PostCovid #covidlonghaulers #CovidLong #pwlc

Last updated 1 year ago
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Tom Kindlon · @tomkindlon
749 followers · 1909 posts · Server disabled.social

Long-Term Dysfunction of Taste Papillae in SARS-CoV-2

tinyurl.com/yc3herd2

“We performed fungiform papillae biopsies on 16 patients who reported taste disturbance lasting more than 6 weeks after […] infection.” “In all patients, we found evidence of , accompanying immune response and misshapen or absent taste buds with loss of intergemmal neurite fibers”

@covid @covid19 @longcovid

#sarscov2 #taste #covid #COVID19 #COVID_19 #PostCovid #pwlc #PostCovid19 #PASC

Last updated 1 year ago
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