Single-nuclei Transcriptomics human Lung
#COVID19 x7
IPF x6
Ctrl x12

COVID🫁
⏫Systemic venous+capillary #EndothelialCell
⏬general capillary EC
⏬Epi-Endo Notch, EC-stromal PDGF
⏫Stromal-EC PlxnA-Sema3A

Dr. Peter Carmeliet lab #CardiovascRes 2022
https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac139/6673943

Partial #EndMT,⏫by #Hypoxia-induced CD45, as a major cellular source for neointima formation

50% ECs in ligated artery are CD45+

CD45 is required to maintain this Partial status
Amazing!🤩

Dr. Yoshito Yamashiro & Yoshito Yamashiro lab #CardiovascRes 2022
https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac190/6942105

How CD45 titrates the extent of mesenchymalization of #EndothelialCell?

CD45 stabilizes VE-cad junction via fortifying integrin α11-SHARPIN complex

Very interesting data on Biomechanics of #EndMT 😋

What (beyond CD45) control partial-to-complete EndMT transition?🤓

Chromatin landscape dynamics of #SmoothMuscleCell in #Atherosclerosis🐭

Integrated scATACseq+scRNAseq+lineage tracing analysis reveals a protective role of ATF3 in atherogenic #Complement 3+ SMC

Dr. Ying Wang & Nicholas Leeper lab #CardiovascRes 2022
https://academic.oup.com/cardiovascres/article/118/13/2792/6438000