.@SarinayElif &co reveal a novel mechanism of growth coordination in #Celegans; inhibition of #ribosome biogenesis in epidermis can trigger organism-wide #GrowthQuiescence, potentially via secreted proteins & the dense-core vesicle pathway #PLOSBiology https://plos.io/3R1jYvq

Cell-cell signaling needs to be precisely controlled for proper development & homeostasis. @melisa_degroot &co @CornellMBG show that the secreted Ca-binding protein SMOC regulates #BMPsignaling in #Celegans by binding to both BMP & glypican #PLOSBiology https://plos.io/47BOphw

"To reverse engineer an entire nervous system" by Haspel et al. 2023 https://arxiv.org/abs/2308.06578

... in which the authors discuss why and how to tackle the brain of the nematode #Celegans.

The engineers throwing down the gauntlet!

@kordinglab I'd start by splitting all neurons into axon and dendrite ... its fairly obvious from the anatomy as recorded at the WormBase, and would let you simplify the activation function of each neuron.

#neuroscience

Screen in #Celegans yields potential targets to delay motor #aging, including the PI3K VPS-34. VPS-34 inhibition improves #neurotransmission & muscle integrity via increased PI(3)P-PI-PI(4)P conversion, improving #MotorAging in worms & mice #PLOSBiology https://plos.io/3XNjhHn

#CElegans chooses between bacterial foods as if maximising economic utility. #Neuroscience https://elifesciences.org/articles/69779?utm_source=mastodon&utm_medium=social&utm_campaign=organic

'These data suggest that animals overexpressing folr-1 are deficient in their ability to adapt to changes in microbial metabolism, thus revealing an intriguing and non-canonical role of folate receptor in lifespan regulation.'
#Preprint #Celegans #metabolism

https://www.biorxiv.org/content/10.1101/2023.06.26.546484v1?med=mas

Throwback to "Periodicity in the embryo: emergence of order in space, diffusion of order in time" with @bradly_alicea and Ujjwal Singh

https://doi.org/10.1016/j.biosystems.2021.104405
@sciencedirect
Biosystems
@OREL

#embryo #embryogenesis #periodicity #develompent #evodevo #bio #biology #embodiment #developmentalbiology #OREL #CognitionFutures #DevoWorm #openworm #celegans

Are there #celegans #worm researchers on mastodon? I'm curious about whether I should spend development time creating a plugin for #jbrowse2 to search for DNA motifs that is similar to the search in JBrowse 1. It would be a non-trivial undertaking. #worm23

@domhenri @MolemanPeter @Andrew_Hardaway @kordinglab

Not that I know of; more than a review it would have to be a book, really, detailing the inner workings of the C. elegans connectome.

Some recent works I've seen:

"Parallel multimodal circuits control an innate foraging behavior", López-Cruz et al. 2019 from @CoriBargmann 's lab

"Forward and backward locomotion patterns in C. elegans generated by a connectome-based model simulation", Sakamoto et al. 2021
https://www.nature.com/articles/s41598-021-92690-2

"Learning the dynamics of realistic models of C. elegans nervous system with recurrent neural networks", Barbulescu et al. 2023
https://www.nature.com/articles/s41598-022-25421-w

See also pretty much all other papers from Cori Bargmannn's lab: https://scholar.google.com/citations?hl=en&user=Wd7XWVYAAAAJ&view_op=list_works&sortby=pubdate

#neuroscience #Celegans #connectomics

@MolemanPeter @Andrew_Hardaway @kordinglab

My reply was directed at the often heard comment that, paraphrasing, states that "the complete connectome of C. elegans is known and yet we don't understand its brain at all", which I have witnessed refuted live by neuroscientists working in the worm who state that the field has a pretty good understanding of what most worm neurons do, and also what most microcircuits do.

#neuroscience #connectomics #Celegans

@Andrew_Hardaway @kordinglab

“is considered impossible” by who? As far as I can tell, there’s steady progress in understanding how the #Celegans nervous system works.

#neuroscience

Various aspects of olfactory memory are represented as modulated responses across different classes of neurons in C. elegans. #Neuroscience #Olfaction #CElegans https://elifesciences.org/articles/87861?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Folded membrane microdomains between the cuticle and epidermis called 'meisosomes' have a role in maintaining and patterning these structures in #CElegans. and its connection with the #ExtracellularMatrix. https://elifesciences.org/articles/75906?utm_source=mastodon&utm_medium=social&utm_campaign=organic

@neuroecology

Looking for #neuroscience? Or #Celegans? or #Drosophila? Or #connectomics? Or #brains, #entomology, #academia, #nativebees? Different place, different approaches – tags here are useful and can be followed.

For accounts, @PhiloNeuroSci selects and comments on neuroscience papers; @eLife and @PLOSBiology publish their papers and digests.

@NicoleCRust challenges us all often; @matrig and @kristinmbranson publish at the intersection of neuroscience and computer science; John @tuthill, @BorisBarbour, Jason Shepherd @jasonsynaptic , @mtarr @gepasi, @cian, @schoppik, @MatteoCarandini, Dan Goodman @neuralreckoning, Bryan @BWJones, @achterbrain, @CoriBargmann and many others publish on neuroscience among other topics.

On open access and #ScientificPublishing there's Stephen Eglen @sje, Stephen Royle @clathrin, and more I can't find quickly now.

I am leaving many out ... the list is long. One way to find them is via tags like #neuroscience.

Big accounts like Doctorow @pluralistic, @Carl_Zimmer, @jwz, and @timkmak are here too. There are many more.

There are useful bots like, for me, @flypapers – I wish I could filter for neuro-only papers, but the volume isn't high. Then there're neuroscience-specific servers like synapse.cafe and neuromatch.social – their local timelines may reveal further accounts you may like.

Folded membrane microdomains between the cuticle and epidermis called 'meisosomes' have a role in maintaining and patterning these structures in #CElegans. and its connection with the extracellular matrix. #CellBiology https://elifesciences.org/articles/75906?utm_source=mastodon&utm_medium=social&utm_campaign=organic

@CoriBargmann @biorxivpreprint

Tagging as #neuroscience #Celegans #behavior for easy discovery/search and so that it appears on the feeds of those who follow these hashtags.

In humans, #D2HGDH mutations cause developmental delay, seizures & #ataxia. Study shows that in nematode #Celegans, D2HGDH sustains #KetoneBody production to support embryonic viability; loss causes #mitochondrial defects & embryonic lethality #PLOSBiology https://plos.io/41r41k4

In humans, #D2HGDH mutations cause developmental delay, seizures & #ataxia. Study shows that in nematode #Celegans, D2HGDH sustains #KetoneBody production to support embryonic viability; loss causes #mitochondrial defects & embryonic lethality #PLOSBiology https://plos.io/41r41k4

In humans, #D2HGDH mutations cause developmental delay, seizures & #ataxia. Study shows that in nematode #Celegans, D2HGDH sustains #KetoneBody production to support embryonic viability; loss causes #mitochondrial defects & embryonic lethality #PLOSBiology https://plos.io/41r41k4

"The structure and function of neural connectomes are shaped by a small number of design principles", by Haber, Wanner, Friedrich, Schneidman, 2023 https://www.biorxiv.org/content/10.1101/2023.03.15.532611v1

"we learn probabilistic generative models for the connectomes of the olfactory bulb of zebrafish, part of the mouse visual cortex, and of C. elegans. We show that, in all cases, models that rely on a surprisingly small number of simple biological and physical features are highly accurate in replicating a wide range of properties of the measured circuits."

"we simulate synthetic circuits generated by our model for the olfactory bulb of zebrafish and show that they replicate the computation that the real circuit performs in response to olfactory cues."

#connectomics #zebrafish #mouse #Celegans #neuroscience