Very interesting case report of pulse methylprednisolone in treatment of steroid-refractory #Immune #CheckPointInhibitor #pneumonitis

We also treated a patient with a grade IV pneumonitis with high dose steroid. My observation is a very rapid improvement, within 48h.

Further research is needed but it could be promising for life-threatening immune checkpoint inhibitor reaction

https://pubmed.ncbi.nlm.nih.gov/36119082/

#MedMastodon #FOAMcc #FOAMed

#cancerresearch #Cancerbiology #Clinicalreviews An understanding of the tumor immune response & the role of #immunecheckpoints in immune tolerance . Mechanisms of immune-related adverse events from #Checkpointinhibitor & focused review on autoantibodies and B cells as biomarkers, advancements and future possibilities
📌https://www.frontiersin.org/articles/10.3389/fimmu.2022.991433/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

"Won et al. demonstrate that PD1
inhibitor treatment alone induces
myocarditis in A/J mice, creating a mouse model for immune-checkpoint-inhibitor-associated myocarditis."

#Immunology #Immunotherapy #CheckpointInhibitor

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01480-2?rss=yes&utm_source=dlvr.it&utm_medium=twitter