Stephen Matheson🌵🌲 · @sfmatheson
709 followers · 691 posts · Server fediscience.orgmodel system PtK2 cells (rat kangaroo), have very diverse #chromosome sizes (short and long)
"polar ejection force" due to #kinesins (Kid and KIF4a) on chromosome arms, they showed that this force is greater in longer chromosomes
error correction takes longer in the larger chromosomes, can reverse this by chopping them up with laser
add extra kinesins → increase force → more errors (slower correction)
Interesting question: is there #evolution pressure to homogenize chromosome size?
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#evolution #kinesins #Chromosome
Stephen Matheson🌵🌲 · @sfmatheson
709 followers · 690 posts · Server fediscience.orgSophie Dumont at UCSF
http://www.dumontlab.ucsf.edu/
#Chromosome size alters #kinetochore attachment stability and alignment order in mammalian #mitosis
Lab interested in #SelfOrganization and emergent mechanics across scales.... "biological structures build themselves" using only local cues they get global information. mitotic spindle a great example
kinetochores attach, sense tension, can make mistakes which are corrected. how does this work when chromosomes vary in size?
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#cssinglecells23 #selforganization #mitosis #kinetochore #Chromosome
American Naturalist · @ASNAmNat
1936 followers · 151 posts · Server ecoevo.socialCryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
#sexchromosome #Chromosome #polygenic #sexdetermination
Charles Plessy · @charles_plessy
2 followers · 21 posts · Server fediscience.orgGvozdenov, Barcutean and Struhl, from the Harvard Medical School, created an artificial #chromosome containing 18 kilobases of random sequence, and studied its expression in yeast. It transcribed high but variable levels of #RNA molecules, which were less stable that their counterpart from the yeast genome. This supports the idea that most RNA polymerases in a cell are just generating noise. This was one of my most exciting reading this year!
The EMBO Journal · @embojournal
439 followers · 156 posts · Server sciencemastodon.com
A #CRISPR-Cas9-tagging approach to induce #chromosome-specific segmental #aneuploidies: targeted assembly of ectopic #kinetochores at endogenous repeats - a way to recapitulate and study specific disease-associated #missegregation events in human cells
@McClellandLab
https://www.embopress.org/doi/10.15252/embj.2022111587
#crispr #Chromosome #aneuploidies #kinetochores #missegregation
The EMBO Journal · @embojournal
431 followers · 152 posts · Server sciencemastodon.com
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1.
#celldivision #Chromosome #staphylococcus #aureus #ftsk #chaperone #triggerfactor #septum #peptidoglycan #hydrolase
Alan Kotok · @technewslit
729 followers · 238 posts · Server journa.host
Fox Foundation Funds New Genetic Variation Targets for Parkinson’s
A Parkinson's disease organization is giving a #grant to a #neurodegenerative #therapies developer that targets new groups of underlying disease-causing #genetic changes.
https://sciencebusiness.technewslit.com/?p=44542
#News #Science #Business #Biotechnology #ParkinsonsDisease #Neuron #Brain #Genes #MichaelJFoxFoundation #Neuroscience #Chromosome #Dopamine #Mutations
#grant #neurodegenerative #therapies #genetic #News #science #business #biotechnology #parkinsonsdisease #neuron #brain #genes #michaeljfoxfoundation #neuroscience #Chromosome #dopamine #Mutations
Andrew Hipp · @andrewlhipp
538 followers · 366 posts · Server ecoevo.social
A needed study of the #chromosome rearrangements that differentiate species (and possibly drive #speciation) in holocentric organisms (here, #butterflies, #lepidoptera).
#Chromosome #Speciation #butterflies #lepidoptera
Kurianlab · @kurianlab
69 followers · 206 posts · Server sciencemastodon.comRT @CrestOptics
🔬Image of the week #CrestOptics
Long-term #DeepSIM imaging of HeLa cells stained with @spirochrome SPY 505-DNA to visualize #chromosome behaviour. Image quality of the #subcellular structures is preserved over time.
#FluorescenceFriday
#crestoptics #deepsim #Chromosome #subcellular #fluorescencefriday
Pierre Lindenbaum · @yokofakun
843 followers · 827 posts · Server genomic.socialideogram #JavaScript #library for #chromosome #visualization. v1.41 released https://github.com/eweitz/ideogram/releases/tag/v1.41.0
#javascript #library #Chromosome #visualization
IMBE · @imbe
365 followers · 444 posts · Server ecoevo.social
Cyto-genotoxicity of tritiated stainless steel and cement particles in human lung cell models https://doi.org/10.3390/ijms231810398 #IMBEpapers
#stainless #steel #particles #cement particles #tritium #InVitroTesting #cytotoxicity #micronuclei #DNA damage #chromosome damage BEAS-2B cells #MucilAirTM
#imbepapers #stainless #steel #particles #cement #tritium #invitrotesting #cytotoxicity #micronuclei #dna #Chromosome #mucilairtm
Rob Waterhouse · @rmwaterhouse
414 followers · 56 posts · Server ecoevo.social
UPDATE: #Arthropod #Genome Assembly Assessment Catalogue: A3Cat v.2022-12-02 with BUSCOv5.4.0 covering 3'514 assemblies from 2'105 species, and with 3'400 species with ongoing or planned genome generation by ERGA, DToL, i5K, & others
🐞 60 #arthropod orders represented
🐝 27 orders with 5 or more assemblies
🦋 748 assemblies labelled as #chromosome level
🦂 291 assemblies for non-#insect arthropods
🦐 428 assemblies with #gene annotations
🕷️ https://rmwaterhouse.org/a3cat
#Arthropod #genome #Chromosome #insect #gene
The EMBO Journal · @embojournal
301 followers · 37 posts · Server sciencemastodon.com
How do #yeast cells adapt to high rates of #chromosome #missegregation?
Chris Campbell and coworkers @maxperutzlabs define serial alterations from specific #aneuploidies, #karyotype refinement, point #mutations, to loss of beneficial copy number alterations
#yeast #Chromosome #missegregation #aneuploidies #karyotype #Mutations
genomeresearch · @genomeresearch
441 followers · 4 posts · Server genomic.social
New in @genomeresearch: Mosaic loss of #Chromosome Y (LOY) was enriched in #microglia cells, increased with age, and was elevated in #Alzheimer’s and Huntington’s disease donors.🧠 Free #openaccess article here: http://ow.ly/JSc250LZzlX #
#Chromosome #Microglia #Alzheimer #openaccess
Arun Kumar Ganesan · @genome_voyager
8 followers · 2 posts · Server mastodon.world
Interested in learning how #lncRNAs could rewrite #epigenetic memory by mislocalizing an histone variant and account for #chromosome instability? 🧬💥
Visit my poster B281 @ASCBiology #CellBio2022
Tue, Dec 6, 12.15pm
#lncrnas #epigenetic #Chromosome #cellbio2022
Point Mutation · @Point_Mutation
212 followers · 1 posts · Server genomic.socialHello Mastodon! 🔬🧬 #introduction
I'm Karissa, a #molecular #biologist with a background in model organism #genetics (specifically #brewing #yeast). I did my undergrad at #dalhousie, & then a PhD at #ubc focusing on #chromosome instability mechanisms in #cancer. I then spent a couple years postdoc'ing & exploring the wild world of #microbial #biodiversity & #screening thru #highthroughput #automation.
I'm keeping this pseudonym from Twitter but everyone knows it's me at this point. 😁
#introduction #molecular #biologist #genetics #brewing #yeast #Dalhousie #ubc #Chromosome #cancer #microbial #biodiversity #screening #highthroughput #automation
Atreya · @at_ray_o
21 followers · 3 posts · Server sciencemastodon.com
I am presenting this poster at #neurips2022 at the #mlsb workshop. If you are here, you are probably already interested in #MachineLearning. If you are also interested in #PolymerPhysics and #chromosome #structures, come check it out. #3dgenome #deeplearning
#NeurIPS2022 #mlsb #MachineLearning #polymerphysics #Chromosome #structures #3dgenome #deeplearning
Scientific European · @ScientificEuropean
210 followers · 258 posts · Server toot.community#Genetic Studies Reveal #Europe has at least Four Distinct #Population Groups | Studies of the regions of Y #chromosome that are inherited together (#haplogroups), reveal Europe has four population groups, namely #R1b-M269, I1-M253, I2-M438 and R1a-M420, pointing to...
#genetic #europe #population #Chromosome #haplogroups #R1b
Victor A. Albert · @PlantEvoGenomics
0 followers · 2 posts · Server ecoevo.social
Not too long ago we completed #sequencing the #genome of the tiny slipper #orchid #Mexipedium xerophyticum - a nearly #chromosome level #GenomeAssembly. We are doing a bunch of #evolutionary #bioinformatics analyses of its #dna
#sequencing #genome #orchid #mexipedium #Chromosome #GenomeAssembly #Evolutionary #bioinformatics #dna
Andrew Hipp · @andrewlhipp
215 followers · 58 posts · Server ecoevo.social
Belatedly, I am a plant systematist at The Morton #Arboretum, with active projects in #oaks (#phylogenetics / #phylogenomics, #hybridization, #introgression, genetic and functional #diversity), #prairies (effects of #phylogenetic and functional diversity on #restoration outcomes), #sedges (#genome and #chromosome evolution), and other plant groups. I also tweet on #botany and #NaturalHistory of the #Chicago region and other areas. Meet my lab at: https://systematics.mortonarb.org
#arboretum #oaks #phylogenetics #Phylogenomics #Hybridization #Introgression #diversity #prairies #phylogenetic #restoration #sedges #genome #Chromosome #botany #naturalhistory #chicago #introduction