#IDMastodon #Publichealth #Viralimmunology high levels of exposure to #SARSCoV2 may reduce protection from #COVID19 vaccines and prior infection of 🦠 The #Clinicalstudy suggests that in crowded environments, that methods to reduce exposure such as masking😷 and social distancing, may help prevent new infections among people who have been vaccinated or have contracted the disease in the past.

#IDMastodon Finding the needle in the hay stacks where is the good information on #COVID19 from ? in this r=#Clinicalstudy only 100 most cited publications out of 552,828 publications in the field of “#infectiousdiseases ” in the WOS database were evaluated bibliometrically. “Web of Science” database “advanced mode” feature was used @MedicineLWW

#Cardiooncology Effectiveness & safety of #anticoagulants among #venousthromboembolism cancer patients with /WO #braincancer .#clinicalstudy of 30,586 patients with active cancer .#apixaban vs LMWH & warfarin was lower risk of rVTE, MB & CRNMB. MB for apixaban vs LMWH with a higher reduction among those with #braincancer @isth
📌 https://www.sciencedirect.com/science/article/abs/pii/S0049384823001019?dgcid=raven_sd_aip_email
📌 https://www.sciencedirect.com/journal/thrombosis-research

#IDMastodon in this #Clinicalstudy A Fully Vaccinated - #Omicron- infected patients vs patients infected with pre-Omicron variants showed a slight increase in viral aerosol shedding during breathing activities, and were more likely to have persistent aerosol shedding beyond 7 days post-disease onset. This follow-up study reaffirms the aerosol shedding properties of Omicron, and should guide continued 😷 of #publichealth interventions even in highly vaccinated populations.

#IDMastodon #Cardiomastodon @Cells_MDPI this is the first #Clinicalstudy to evaluate Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in #COVID19
📌 https://www.mdpi.com/2073-4409/12/6/87
📌 https://www.mdpi.com/journal/cells/special_issues/Stress_Cardiovascular
📌 https://www.mdpi.com/2073-4409/12/6

#IDMastodon In recent #Clinicalstudy study in @SciSignal demystifies how an enzyme coordinates nutrient retention in the #kidneys—and hints that targeting this enzyme may protect kidney cells from infections with viruses such as #SARSCoV2 .A renal gatekeeper for nutrients and viruses
📌https://www.science.org/doi/10.1126/scisignal.abo7940?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial
📌 https://www.science.org/journal/signaling
📌 https://www.science.org/toc/signaling/16/775

#IDMastodon #Immunology #Clinicalreports #Clinicalstudy @jacionline. #Lymphopenia, particularly restricted to #Tcell compartment, has been described as one of the major clinical hallmarks in COVID-19 patients and proposed as a disease severity indicator. @Velardi_Lab et al demonstrate that the human thymus is a target of #SARSCoV2 & that thymic function is impaired in #COVID19 patients.
https://www.jacionline.org/article/S0091-6749(23)00147-1/pdf

@ScienceMagazine A #Clinicalstudy demonstrates that a protein exclusively produced by the liver plays an unexpected role in the heart & protects it in response to triggers of pathological remodeling. Liver-derived coagulation factor XI protects the heart from failure
https://www.science.org/doi/epdf/10.1126/science.ade2538

#IDMastodon #CardioMastodon #Clinicalstudy myocarditis after vaccination with #SARSCoV2 mRNA vaccines was associated with a lower risk of HF within 90 days of admission to hospital vs conventional myocarditis & #myocarditis after #COVID19 via @SABOURETCardio
📌https://bmjmedicine.bmj.com/content/bmjmed/2/1/e000373.full.pdf
📌 https://bmjmedicine.bmj.com/content/2/1/e000373
📌 https://bmjmedicine.bmj.com/content/2/1

#IDMastodon #COVID19 #Clinicalstudy @aaas Repeat #SARSCoV2 mRNA Vaccination Tied to Rise in Unexpected Antibody Subset. The rise doesn’t impact vaccine effectiveness, but the new insights could help optimize future mRNA #vaccines.
📌 https://www.aaas.org/news/repeat-sars-cov-2-mrna-vaccination-tied-rise-unexpected-antibody-subset

#cardiooncology #clinicalstudy Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction
https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00156-3

#IDMastodon #CardioToote #Cardiology While myocardial impairment is a predictor of poor prognosis in antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV), little is known about valvular involvement. This #Clinicalstudy aims at describing the clinical presentation, management, and outcome of endocarditis associated with AAV. @jrheum
https://www.jrheum.org/content/49/12/1349.full?ijkey=3FYqRpCBkXruw&keytype=ref&siteid=jrheum

#PedsICU #IDMastodon Pediatric patients are more likely than adult patients to experience mild #SarsCoV2 infection but may still suffer severe infection with lasting sequalae or death. In this #Clinicalstudy suggested MABs are well-tolerated & effective for preventing severe #COVID19 or death among high-risk pediatric patients & for decreasing the health burden of #COVID19 during surges.
📌 https://academic.oup.com/ofid/article/9/Supplement_2/ofac492.1779/6903932?login=false#.Y5wxTJyhFF8.twitter
📌 https://academic.oup.com/ofid/article/9/Supplement_2/ofac492.924/6903272?searchresult=1
📌 https://academic.oup.com/ofid/article/9/Supplement_2/ofac492.1494/6903395?searchresult=1
📌 https://academic.oup.com/ofid/issue/9/Supplement_2

#IDMastodon Omicron variants bind with higher affinity to motile cilia and show accelerated viral entry. In this #Clinicalstudy that motile cilia, microvilli, and mucociliary-dependent mucus flow are critical for efficient virus replication in nasal epithelia. @CellCellPress . Based on this study ,please wear n-95 😷 wherever you are & mostly in enclosed places to minimise the rate of #SarsCoV2 infection & reduce that’s hight viral loads
https://www.cell.com/action/showPdf?pii=S0092-8674%2822%2901505-7

#IDMastodon C-Reactive Protein (CRP): A poor prognostic biomarker in #COVID19 . In this #Clinicalstudy CRP value of ≥100mg can be correlated to the disease’s severity as well as a high risk of mortality. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1040024/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit @FrontImmunol

#Oncomastodon #cancerresearch The first GWAS on mammographic texture variation in ~7000 women. This #Clinicalstudy identified novel texture variation loci and shared loci between texture variation, mammographic density, and #breastcancer risk
📌https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-022-01570-8 @_YuxiLiu @bmc
📌https://breast-cancer-research.biomedcentral.com