Alexis Verger · @AVerger
1265 followers · 248 posts · Server fediscience.org

Want !!!!

#CryoEM

Last updated 1 year ago

Ed Eng · @edwardeng
57 followers · 9 posts · Server fediscience.org

Today is the last day to register for the NYC integrative structural biology symposium () on Oct 13, 2023.

For more information see:
nysbc.org/nyc-isb23

@SEMC_NYSBC - Providing expertise & resources for understanding molecular & cellular structure

#CryoEM #nycisb23

Last updated 1 year ago

To illustrate the concept of discrete conformational heterogeneity in , I ended up using these two EMDB entries:

- EMD-4774 ebi.ac.uk/emdb/EMD-4774
- EMD-4780 ebi.ac.uk/emdb/EMD-4780

#CryoEM

Last updated 1 year ago

When the whole world suddenly wanted to do at the same time (around 2017) and grids were back ordered for months from all makers and distributors.

Nowadays thankfully @quantifoil is on top of things. 👍

(Found from wandering.shop/@realtegan/1107 )

#cryomeme #meme #CryoEM

Last updated 1 year ago

#CryoEM

Last updated 1 year ago

In 2021, I was happy to publish a paper and poster this 🧵 about it on 🐦 : twitter.com/Guillawme/status/1

But I had messed up the @emdb_empiar deposition, so the entry was in limbo for a very long time. This got fixed recently, and the entry is finally released now!

ebi.ac.uk/empiar/EMPIAR-10739/

You will find the raw movies and extracted particles that were used for the cryoDRGN analysis and the corresponding @PDBeurope deposition (7OTQ).

#CryoEM

Last updated 1 year ago

François Ferron 🇪🇺 · @F2erron
77 followers · 282 posts · Server fediscience.org
François Ferron 🇪🇺 · @F2erron
77 followers · 282 posts · Server fediscience.org

Very interesting article on
Structures of dengue virus RNA replicase complexes: Molecular Cell
cell.com/molecular-cell/fullte

#CryoEM #polymerase #replicationcomplex #denguevirus

Last updated 1 year ago

John Rubinstein · @JohnRubinstein
239 followers · 7 posts · Server fediscience.org

Now published in the Journal, Gautier Courbon compares mycobacterial ATP synthase inhibitors TBAJ-876 (from TBAlliance) & SQ31f (from AstraZeneca, synthesized by Paul Palme in Imming lab Universitat Halle) to the essential medicine bedaquiline (BDQ).
t.co/bQAQkPKppG


-discovery

#drug #tuberculosis #CryoEM #TB #embo

Last updated 1 year ago

PLOS Biology · @PLOSBiology
4983 followers · 1610 posts · Server fediscience.org

Modulating itch sensation: structure of human MRGPRX1-Gq complex with agonist reveals a unique agonist recognition pattern compared to other MRGPRXs, with potential therapeutic implications for & plos.io/3NLqpAA

#plosbiology #analgesia #itchrelief #itchreceptor #CryoEM

Last updated 1 year ago

Luca Jovine · @lucajovine
55 followers · 9 posts · Server fediscience.org

In this work, we combine , , predictions, biochemical and mouse studies to unveil the 3D structure of vertebrate egg coat filaments and describe how cleavage of their subunit hardens the coat, establishing a permanent block to .

A very big thank you to all co-authors, collaborators, and funding bodies for making this possible!

#polyspermy #zp2 #alphafold #CryoEM #crystallography

Last updated 1 year ago

CellBioNews · @cellbionews
58 followers · 1415 posts · Server scientificnetwork.de

Hello fediverse! I am trying to illustrate the concept of discrete conformational heterogeneity. Do you know EMDB entries showing the same molecule in two very distinct conformations? (preferably both coming from the same dataset).
Thanks!

#CryoEM

Last updated 1 year ago

DrSarahEJBowman · @XtalMaker
302 followers · 434 posts · Server fediscience.org

"Garbage In, Garbage Out" - how many times have you heard this expression in structural biology?!?!

We are running a workshop on sample preparation techniques at the upcoming 2023 American Crystallographic Association meeting July 7, 2023 in Baltimore, MD - register by June 30!

acameeting.com/workshop2-sam23

#StructuralBiology #workshop #auc #lightscattering #crystallography #Crystallization #CryoEM #SAXS #structural

Last updated 2 years ago

PLOS Biology · @PLOSBiology
4863 followers · 1426 posts · Server fediscience.org

of yeast methionine aminopeptidase & N-acetyltransferase B in complex with reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab plos.io/3n0S1an

#plosbiology #ribosomes #CryoEM

Last updated 2 years ago

PLOS Biology · @PLOSBiology
4863 followers · 1409 posts · Server fediscience.org

of yeast methionine aminopeptidase & N-acetyltransferase B in complex with reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab plos.io/3n0S1an

#plosbiology #ribosomes #CryoEM

Last updated 2 years ago

PLOS Biology · @PLOSBiology
4863 followers · 1406 posts · Server fediscience.org

of yeast methionine aminopeptidase & N-acetyltransferase B in complex with reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab plos.io/3n0S1an

#plosbiology #ribosomes #CryoEM

Last updated 2 years ago

Rich Posert · @posertinlab
90 followers · 48 posts · Server fediscience.org

Did you take linear algebra? I'd like to learn it but didn't take it in college, and I'm looking for books people like!

#honestlyweirdthatweletessentiallychildrenpicktheirmajor #machinelearning #CryoEM #math

Last updated 2 years ago

Alexis Verger · @AVerger
1209 followers · 228 posts · Server fediscience.org

In the recent years, we have seen

revolution

genomic tagging for endogenous affinity purification revolution

revolution

Diffusion model revolution

What a time to be in !!!

#StructuralBiology #design #protein #ai #alphafold #crispr #CryoEM

Last updated 2 years ago