Pleased to share that the lab has landed its first R01 to study the role of lactate transport as a potential metabolic vulnerability in pulmonary fibrosis!

#cureIPF

RT @KerriBerriKerri@twitter.com

🌟From Dr. Carl Reynolds et al.🌟
Occupational asbestos exposure alone does not⬆️risk of #IPF
👉asbestos+smoking interact➡️#IPF w/ MUC5B allele
66% cases/63% controls high/med exposure risk😬
8% v. high cumulative exposure😬
#AsbestosBan #CleanAir #CureIPF
https://oem.bmj.com/content/early/2023/01/12/oemed-2022-108404

8/n last - Study funding was by @boehringerus@twitter.com #DiscoveryAward to @Farida_Ahangari@twitter.com & by @nih_nhlbi@twitter.com to me & others, also supported by institutional cores, colleagues, patient advocates, sample & tissue donors
Thank you all!!!
#CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

7/n So grateful to the team, led by Dr. Ahangari, #KaminskiLab members, so many selfless collaborators including Drs Fernández-Hernando, Price, Dela Cruz, Prasse, Ivan Rosas, & Bahal (https://bahal.lab.uconn.edu/ that designed PNA-33) #CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

6/n Pharmacologic inhibition of miR-33 using PNA-33 in precision-cut lung slices obtained from bleomycin-injured mice or humans with IPF, also indicated antifibrotic effects, including reversal of profibrotic macrophage signature
#CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

5/n Impressively, loss of Mir-33 in myeloid cells, has an effect on alveolar type II cells, their mitochondrial homeostasis improved and apoptosis ⬇️
#CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

4/n Loss of miR-33 in macrophages improves mitochondrial homeostasis (function and structure) at baseline and after bleomycin injury, ⬆️ autophagy and mitophagy #CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

3/n Knocking down miR-33 genetically in myeloid cells, or pharmacologically using a Peptide Nucleic Acid inhibitor designed by Dr. Bahal (PNA-33) protects mice against bleomycin-induced Pulmonary Fibrosis
#CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

2/n We first show that miR-33 is increased in BAL and lung cells obtained from IPF patients and that miR-33 target genes are decreased in IPF
#CureIPF #miR33PFPaper
https://insight.jci.org/articles/view/158100

Intriguing! Connections between air pollution, and DNA methylation in IPF. Kudos Drs Dr. Goobie, Zhang & team
#CleanAir
#CureIPF
https://www.sciencedirect.com/science/article/abs/pii/S0269749122021571

Really cool for last day of 2022 - decellularized ECM composition of specific anatomical lung regions in non-disease, COPD, and IPF human lungs. Kudos Drs Hoffman, Weiss & team
#CureCOPD #CureIPF #ECMRules https://www.sciencedirect.com/science/article/abs/pii/S0142961222006007

RT @KerriBerriKerri@twitter.com

@REMAP_ILD@twitter.com @IPFdoc@twitter.com @leticiakawano@twitter.com @RogerJLewis@twitter.com @BerryConsultant@twitter.com @KaminskiMed@twitter.com @PilarRiveraOrt1@twitter.com @ActionPFwendy@twitter.com @pfsg_nireland@twitter.com @ActionPFcharity@twitter.com It’s an honour to be part of such a collaborative endeavour 😊🤩 to #CurePF #CureIPF 🫁
#SiSePuede

RT @PilarRiveraOrt1@twitter.com

@REMAP_ILD@twitter.com @IPFdoc@twitter.com @leticiakawano@twitter.com @RogerJLewis@twitter.com @BerryConsultant@twitter.com @KaminskiMed@twitter.com @KerriBerriKerri@twitter.com @ActionPFwendy@twitter.com @pfsg_nireland@twitter.com @ActionPFcharity@twitter.com It is a privilege to be part of this fabulous team worldwide 🌎 @REMAP_ILD@twitter.com We are a great family 🤗🫁 I wish all of you a Happy 2023! 🎇🎉🎊 #ILD #IPF #CureIPF #teamwork

RT @KerriBerriKerri@twitter.com

@KaminskiMed@twitter.com @IPFdoc@twitter.com @charlot_summers@twitter.com @WesElyMD@twitter.com @DelaCruzYaleMed@twitter.com @DrPujaMehta1@twitter.com @ProfJDChalmers@twitter.com @smlungpathguy@twitter.com @terrilaguna@twitter.com @nickmmark@twitter.com #BestInResp2022 #BestILDConference for learning, sharing, collaborating, and inspiring #ICLAF2022 🇮🇸 #CurePF #CureIPF
H/T @ggudmund@twitter.com @IPFdoc@twitter.com
Find meeting highlights using the #

RT @RobertMTighe1@twitter.com

Awesome to have @KaminskiMed@twitter.com for Visiting Pulmonary Scholars #VPS talking about advances in IPF and how RNA provides a roadmap to #CureIPF @YalePCCSM@twitter.com @DukePACC@twitter.com @UNCCEMALB@twitter.com

RT @KerriBerriKerri@twitter.com

Machine Learning in Radiology: The New Frontier in ILD
From @hayleynbarnes@twitter.com et al. in @LancetDigitalH@twitter.com

Comprehensive, accessible overview of machine learning, AI, radiomics (+more!) applications to #ILD 🫁

#OpenAccess #CurePF #CureIPF 🎯

https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00230-8/fulltext

RT @KaminskiMed@twitter.com

Wow! Congratulations Dr. Ahangari!
#CureIPF https://twitter.com/yalepccsm/status/1601632504913752064

Wow! Congratulations Dr. Ahangari!
#CureIPF

RT @YalePCCSM@twitter.com

Congratulations Dr. Farida Ahangari for earning second place award at the @Yale_Ventures@twitter.com #PitchFest2022.
Many more to come!
We are all proud!!
#BestFaculty
#ThisIsYalePCCSM

RT @IPFdoc@twitter.com

They should certainly try. Coz if #rheum #CureIPF they will reduce burden of #RA. Coz IPF ➡️ RA. 😉 https://twitter.com/KaminskiMed/status/1599297327159648256

👇🏼

RT @IPFdoc@twitter.com

@TamesideGroup@twitter.com @TobyMMaher@twitter.com @ILDIPFDoc_NI@twitter.com @PilarRiveraOrt1@twitter.com This is really 😎 study from @Paulwnoblemd@twitter.com & colleagues showing crucial importance of ZIP8 in #IPF which regulates zinc metabolism in key cells causing fibrosis. It DOES NOT show taking zinc helps #CureIPF. Further studies are required to show this! Perhaps @REMAP_ILD@twitter.com will help.