In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience
#Maize #BRCA2 #meiotic #Recombination #arabidopsis #plantsci #evolution #DNARepair #JIPB #plantscience
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565
#brca1 #e3 #ligase #nucleosome #chromatin #ubiquitylation #DNARepair
The PLK1 kinase mandates DNA polymerase theta to safeguard the #genome during #mitosis.
#preLighter Pierre Caron covers a #preprint by Camille Gelot #institut_curie and team that redefines the physiological function of #TMEJ.
#DNArepair #GenomeStability
https://prelights.biologists.com/highlights/pol%ce%b8-is-phosphorylated-by-polo-like-kinase-1-plk1-to-enable-repair-of-dna-double-strand-breaks-in-mitosis/
#genome #mitosis #prelighter #preprint #institut_curie #tmej #DNARepair #genomestability
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities
@CellReports
by Llorca Lab (cniostopcancer ), The Moreno-Herrero Lab (CNB_CSIC), Fortes Lab (CIMA Universidad de Navarra)
Very nicely explained here ⬇️
https://cnio.es/en/news/one-of-the-causes-of-aggressive-liver-cancer-discovered-a-molecular-staple-that-helps-repair-broken-dna/
#cnio #cniostopcancer
#scicomm #cancer #genetics #sketchnote #yourscienceinasketch #hepatocellularcarcinoma #noncodingRNA #dnadamage #DNArepair #biophysics #magnetictweezers #comunicaciencia
#comunicaciencia #magnetictweezers #biophysics #DNARepair #DNAdamage #noncodingrna #hepatocellularcarcinoma #yourscienceinasketch #sketchnote #genetics #cancer #scicomm #cniostopcancer #CNIO
Thrilled to share this work about NIHCOLE, in collab with CNIOSTOPCANCER,
summarizing the great work about its mechanism and role in #DNARepair published in
@CellReports
#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961
#dnadamage #DNARepair #Kinase #dnapk #cgas #inflammation #glioblastoma
For more information, see below
http://www.ciccialab.com
#DNADamage #DNARepair #GenomeEditing #CRISPR
#DNAdamage #DNARepair #genomeediting #crispr
We have open postdoctoral positions to study the DNA damage response at nucleotide resolution using base editing screens or develop new precision genome editing applications. Come and join us! #DNADamage #DNARepair #GenomeEditing #CRISPR http://www.ciccialab.com
#DNAdamage #DNARepair #genomeediting #crispr
An excellent review from the Liston lab on #DNARepair defects, highlighting a disproportionate effect in #Leukocytes leading to #PID
https://www.sciencedirect.com/science/article/pii/S0091674922015147
#DNARepair #leukocytes #pid #immunology #Science
#Covid “ #vaccine ” #spikeproteins destroy #DNArepair #pathways, paving the way for #CANCER to grow and spread https://bit.ly/3BT4rmj
#cancer #pathways #DNARepair #spikeproteins #vaccine #COVID