It's not just about the drugs themselves. #DrugDisease and #DiseaseProgression models are also an area in which #Pharmacometrics continues to have an impact - #FDA maintains a list the ones they've developed internally, including examples for #Alzheimers and #Diabetes, although there are many, many more.

https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/division-pharmacometrics

Pharmacometrics rolls up modeling and simulation for #Pharmacokinetics, #Pharmacodynamics, and #DiseaseProgression, with a focus on populations and variability. A major focus is to understand variability in drug response, which can be predictable (e.g. due to differences in body weight or kidney function) or unpredictable (differences between subjects seem random, but likely reflect a lack of knowledge or data).

https://en.wikipedia.org/wiki/Pharmacometrics