TrangAston :verified: · @CastlTrAstonDrs
1434 followers · 3101 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1361 followers · 2812 posts · Server med-mastodon.com
Gabriele Pollara · @gpollara
967 followers · 3078 posts · Server med-mastodon.com

@cyrilpedia nice piece, and also informative. Had missed the black box warning on the whole JAK Stat family! Is the increased cardiovascular risk dose / time dependent, or is it idiosyncratic?

#immunology #DrugDiscovery #DrugDevelopment #alopecia

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1348 followers · 2772 posts · Server med-mastodon.com

@asmicrobiology II for evaluating the activity, safety, efficacy, & of in ambulatory patients with mild/moderate . Although the study ended early and did not meet the primary efficacy end point, bemnifosbuvir was well tolerated and did not contribute to all-cause mortality. vs placebo

#IDMastodon #viralimmunology #DrugDevelopment #phase #clinicaltrial #Antiviral #pharmacokinetics #bemnifosbuvir #COVID19

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1298 followers · 2593 posts · Server med-mastodon.com

on the current & future for therapies as the emergence of new variants of , it is expedient that various therapeutics are researched & developed for the containment of .

#IDMastodon #viraimmunotherapy #Clinicalreviews #DrugDevelopment #COVID19 #SarsCoV2

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1296 followers · 2589 posts · Server med-mastodon.com

@Nature
Not all viruses have high antigenic variability, but for , ,, it will remain a challenge, and those types of antibodies are pretty high risk in the near term, given the rate of viral evolution.

#IDMastodon #DrugDevelopment #immunology #SarsCoV2 #influenza #hiv

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1280 followers · 2508 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1271 followers · 2463 posts · Server med-mastodon.com

@fda_drug_info Approves First Oral ( / tablets, co-packaged for oral use) for the treatment of mild-to-moderate in adults who are at high risk for progression to severe , including hospitalization or death.
fda.gov/news-events/press-anno

#publichealth #DrugDevelopment #Antiviral #Paxlovid #nirmatrelvir #COVID19

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1240 followers · 2307 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1193 followers · 2123 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1187 followers · 2065 posts · Server med-mastodon.com

Happy ! The just approved the first treatment for , a rare, genetic, neurological disorder affecting brain development. This condition affects about 1:10,000 females, males to a far rarer extent and leads to a loss of language and motor skills developed earlier in life.

The medication Daybue (trofinetide) is for people 2 or older, delivered orally or via gastrostomy tube.

#MedicineMonday #FDA #rettsyndrome #DrugDevelopment #RareDisease

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1184 followers · 2004 posts · Server med-mastodon.com

@SciImmunology: In Vivo study identifies a -based pathway connecting and metabolic dysfunctionโ€”suggests certain insulin sensitizer drugs taken alongside could prevent lung damage.
๐Ÿ“Œ science.org/doi/10.1126/sciimm
๐Ÿ“Œ science.org/

#IDMastodon #DrugDevelopment #pyruvate #COVID19 #SarsCoV2 #antivirals

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1181 followers · 1965 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1180 followers · 1962 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1178 followers · 1943 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1148 followers · 1800 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1141 followers · 1747 posts · Server med-mastodon.com

@aaas This study was designed with the goal to identify broadly cross-reactive and cross-neutralizing monoclonal antibodies that could recognize all variants of concern and likely remain effective against future VOC.
science.org/doi/epdf/10.1126/s

#IDMastodon #DrugDevelopment #SarsCoV2

Last updated 2 years ago

RT @tmprowell
Hope @POTUS will talk about in State of the Union address. The US has millions of people newly disabled by a condition without effective treatment, with major health & economic implications. In summary, it belongs in .

#LongCovid #sotu2023 #medtwitter #DrugDevelopment #Regulatory

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1116 followers · 1641 posts · Server med-mastodon.com

@biorxivpreprint
Mucoactive drugs block Infectionโ€จIn this indicates that Intact MCT reduces SARS-CoV-2 infection, andโ€จits pharmacologic activation may be effective as an anti- treatment.
biorxiv.org/content/10.1101/20

#IDMastodon #DrugDevelopment #mucosalimmunity #SarsCoV2 #Clinicalreviews #COVID19

Last updated 2 years ago