#IDMastodon #Immunology #Innateimmunity & #DNA repair are critical sense-response systems that have evolved to protect cells from external & internal threats: tumors, invading pathogens, toxic agents, physical wounds. Both sys are the focus of intense research & #DrugDiscovery activity to enable more effective therapies for cancer & debilitating #autoimmune & #inflammatorydiseases
https://www.bellbrooklabs.com/wp-content/uploads/2023/08/The-DNA-Damage-Response-and-Innate-Immunity-v08252023.pdf

Great talk by Annette Beck-Sickinger at #IUPACCHAINS2023. She talked about the power of peptide-based therapeutics. Exciting applications for GPCR biology, for coatings of implants and for drug delivery. #Chemistry #ChemiVerse #DrugDelivery #DrugDiscovery doi.org/10.1039/c9bm01801h

Great KNCV Golden Medal Award Lecture by Gerard van Westen of @LED3hub at #IUPACCHAINS2023. He talked about his group's work on using computers and AI in drug discovery. Exciting insights into opportunities and current challenges. #Chemistry #ChemiVerse #AI #DrugDiscovery https://doi.org/10.1007/978-1-0716-0826-5_6

Great talk by Andreas Herrmann at #IUPACCHAINS2023. He talked about his group's work on drug delivery and drug release using ultrasound. Exciting insights on mechanical activation by ultrasound using polymers, nanoparticles, microbubbles and nucleic acids. #Chemistry #ChemiVerse #DrugDiscovery https://www.nature.com/articles/s41557-020-00624-8

Great talk by Ali Tavassoli at #IUPACCHAINS2023. He talked about his group's work on the SICLOPPS technology to make and screen large libraries of cyclic peptides directly in living cells. Exciting applications for many difficult drug targets. #Chemistry #ChemiVerse #DrugDiscovery https://doi.org/10.1016/j.cbpa.2017.02.016

Great talk by Ali Tavassoli at #IUPACCHAINS2023. He talked about his group's work on the SICLOPPS technology to make and screen large libraries of cyclic peptides directly in living cells. Exciting applications for many difficult drug targets. #Chemistry #ChemiVerse #DrugDiscovery https://doi.org/10.1016/j.cbpa.2017.02.016

#IDMastodon #Drugdiscovery #Drugdevelopment @DDWJournal #Antibody discovery: Breakthroughs accelerating therapeutic antibodies .Trend and Challenge for therapeutic antibody in pandemic era
https://7915828.fs1.hubspotusercontent-na1.net/hubfs/7915828/DDW%20eBOOK%20ANTIBODY%20DISCOVERY_PROTECTED_FINAL.pdf?hsCtaTracking=b9795c08-6d89-4543-97ad-90cc3c6eae68%7C7aadb240-d29f-4505-a29e-578edfcc66da

@cyrilpedia nice piece, and also informative. Had missed the black box warning on the whole JAK Stat family! Is the increased cardiovascular risk dose / time dependent, or is it idiosyncratic?
#Immunology #drugdiscovery
#drugdevelopment #alopecia

When validating your therapeutic target, don't forget to check whether there is a commonly occurring non-pathogenic mutation that may impair your intended MoA!

#targetdiscovery #drugdiscovery #oncology OmicsChart #omicschart #clinicalresearch

#IDMastodon #Molecularbiology #Drugdelivery #Drugdiscovery #COVID19pandemic has seen no single Rx or combination proven to effectively halt disease progression, & the effect of the massive worldwide vaccination campaign is waning & the thread of near-future surges of this pandemic by #Omicron subvariants. Pharmacological treatments that reduce the risk of progression from #SARSCoV2 infected patients are imperfect, and their efficacy is restricted to the early intervention .

Join us in celebrating our new #collaboration with the Critical Path Institute! Learn more about our work to improve #drugdiscovery for #rarediseases here:
https://link.medium.com/Qkc22sufjAb

#teamscience #translationalscience #healthcare

#IDMastodon @Nature Outline key lessons from rapid #Antiviral drug discovery efforts , or ‘sprints’, & articulate remaining open questions, specifically focusing on target selection, medicinal chemistry strategies, in vitro and in vivo models, and methods to pre-empt resistance. Accelerating antiviral #DrugDiscovery lessons from #COVID19
📌 https://www.nature.com/articles/s41573-023-00692-8
📌 https://www.nature.com/nrd/

RT @thesgconline
📢#JobAlert🚨
@CQMED_Unicamp in Brazil is hiring two #postdocs to work on #drugdiscovery! If you have a background in #molecularbio or #cellbio, apply now!
#postdocposition #jobopportunities
https://www.thesgc.org/careers/campinas-unicamp/center-medicinal-chemistry-brazil-hiring-two-post-docs-work-drug-discovery

RT @thesgconline
"Congratulations to @acceleration_c at @UofT for receiving $200M from #CFREF to continue groundbreaking work in materials and molecular discovery! Proud to be a partner on this initiative and look forward to collaborating on AI-assisted automated #drugdiscovery https://twitter.com/acceleration_c/status/1651962012350464002

RT @XChemInc
DELs, a faster way to tap into the ubiquitin-proteasome system. In supporting @Relay_Tx and @thesgconline, our high-quality DEL data facilitated the discovery of a promising #smallmolecule engager for DCAF1. http://ow.ly/qNMq50NL2Vm

#DEL #drugdiscovery

#DrugDevelopment @NatRevDrugDisc #Clinicalreview Summarize progress with #COVID19 #DrugDiscovery based on accumulated findings since #COVID19pandemic began & a comprehensive list of clinical and preclinical inhibitors with #Antiviral activities.
📌https://www.nature.com/articles/s41573-023-00672-y
📌 https://www.nature.com/nrd/articles?type=review-article
🧵by @imedverse
https://twitter.com/imedverse/status/1651032814467313664?s=61&t=Yz-0chnQVfpDSt8bfrGiCw

RT @CQMED_Unicamp
#hiring

We are happy to announce two post-doc positions in Brazil to join a @thesgconline #drugdiscovery in reproductive biology project.

https://www.cqmed.unicamp.br/cqmed-is-hiring-two-post-docs-to-work-on-drug-discovery-in-reproductive-biology/

Designing #antibodies from scratch was a challenge that Absci undertook. Most #drugdiscovery approaches at the time focused on examining existing antibody libraries for incremental improvements. Recently, Absci demonstrated the design of de novo ant[..] https://parkhealth.io/Absci

💡 Interested in our Call for Application addressing #AI applied to the development of #Molecular Glues?

💡 Watch our webinar to find out more: https://www.youtube.com/watch?v=Z1vgUlzwwfw

💡 To read the full #project description and #apply, go here: https://career.bio.mx/call/2023-AIL-C05.

❓ Questions? Leave them in the comments!

#DrugDiscovery #Research #MedTech #BioTech #Pharma #ML #MachineLearning #ArtificialIntelligence

Interesting #job for Head of #datascience https://www.linkedin.com/jobs/view/3517566033/ #graphdatabase #lifescience #drugdiscovery