Stabilizing FOXF1 to treat #AlveolarCapillaryDysplasia

Chemical screening->TanFe
⏬Ubiquitination of FOXF1 via⏬binding to #E3Ligase HECTD1/SHPRH/NEURL1B etc->

Restoring Lung #Angiogenesis of Foxf1+/-🐭

Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
https://www.atsjournals.org/doi/10.1164/rccm.202207-1332OC

How FOXF1 impacts #EndothelialCell #Angiogenesis?

As a transcription factor for S1PR1 & VE-Cad😎

An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016👇

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

https://www.science.org/doi/10.1126/scisignal.aad1899

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes

A few reads🤠

https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00972-6

https://www.nature.com/articles/jp201494

https://www.nature.com/articles/ejhg2012171

https://www.jpeds.com/article/S0022-3476(04)00647-X/fulltext

K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠

Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy

A #CellCycle-specific regulation of YAP?😆

Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943

#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant

Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1

Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6