Aortic #Endotheliopathy #MarfanSyndrome

En face #EndothelialCell morphometry->
Alterations in EC shape/junction/alignment/eNOS Precede aortic dilation in Marfan🐭

Flow-sensing defect?😆

Dr. Vivian de Waard lab Scientific Reports 2023
https://www.nature.com/articles/s41598-022-26662-5

Causal role of #Endotheliopathy in #Emphysema #COPD 🤠

i.v. Delivery of E4ORF1-transduced Lung #EndothelialCell
Or EC LRG1 (TGFβ/Alk1/Eng modulator) KO
alleviates elastase-induced🐭COPD

Dr. Alexandra Racanelli, Shahin Rafii & Augustine Choi labs J Exp Med 2021
https://rupress.org/jem/article-standard/218/8/e20200938/212491/Reversal-of-emphysema-by-restoration-of-pulmonary