A new method to detect outlier methylation regions, presented by Christine Hansen yesterday at #Epigenomics22. Never thought about the concept of defining rare methylation patterns and counting burden of rare methylation outliers, analogous to burden of rare genetic variants. Some potentially interesting preliminary associations with psychiatric outcomes. Looking forward to the full paper and curious to try myself the method.

https://gitlab.com/CSoeholm/outlier-methylation-analysis-oma

Another talk about long reads: Duncan Sproul on Genome-wide analysis of single-molecule DNA methylation

#Epigenomics22 #epigenetics

Last day: Ariel Gershman from Johns Hopkins reminding us that hg38 is still far from a "finished" assembly of the human genome, which has implication for epigenetics, too

#Epigenomics22 #epigenetics

Elad Segev: Discontinuities aging: finding switch points in DNA methylation

#Epigenomics22 #epigenetics

Andrew Teschendorff on "Cell-type deconvolution of solid tissue DNA methylomes at cell-type resolution" - this one is quite close to my heart, as we're working on similar stuff 😉

#Epigenomics22 #epigenetics

Martin Hirst - EpiATLAS, a reference for epigenetic research

Useful resource: IHEC - the International Human Epigenome Consortium

https://ihec-epigenomes.org/

#Epigenomics22 #epigenetics

Rama Natarajan now talking about Epigenetics and noncoding RNAs in #diabetes

#Epigenomics22 #epigenetics

B-cell involvement in MS: EBV latent in MS B-Cells, alterations to the epigenome (predominant hypomethylation) ➡️ Age associated B-cells?

#Epigenomics22 #epigenetics

methylation differences distinguish risk groups of MS progression. Searching for genetic predisposition conditional on DNAm revealed HLA differences between progressing and non-progressing groups #Epigenomics22 #epigenetics

First up: Maja Jagodic from Karolinska Institute talking about mechanisms of Multiple Sclerosis development and progression

#Epigenomics22 #epigenetics

Not sure how interested anyone in my network is in my live-tooting of talks from the #Epigenomics of Common Disease 2022 conference? Anyway, I'll keep going for now 🙃

#Epigenomics22 #epigenetics

Sonia Garcia-Calzon - Novel subgroups of type 2 #diabetes reveal different DNA methylation patterns:

adipose tissue methylation changes distinguish subtypes, and some of these are detectable also in blood. Also predict future risk of complications.

#Epigenomics22 #epigenetics

Short talks now: Marie de Borre on cfDNA detection of
#preeclempsia using methylation changes. Use CpG sites with placenta-specific methyl. as markers. Early detection before usual diagnosis has high AUC #Epigenomics22 #epigenetics

"spatial multi-omic heart atlas": link spatial transcriptomics with single-cell RNA and epigenetics. Also sampling over multiple timepoints including accute myocardial infarction.

#Epigenomics22 #epigenetics

"spatial multi-omic heart atlas": link spatial transcriptomics with single-cell RNA and epigenetics. Also sampling over multiple timepoints including accute myocardial infarction.

#Epigenomics22 #epigenetics

Next: Christoph Kuppe from Aachen talking about Spatial and single cell multi-omic analysis of human heart disease

#Epigenomics22 #epigenetics

Regulation of ZBTB16 prob directly regulated by gccs through altering methylation levels around gcc response element in the enhancer. #Epigenomics22 #epigenetics

in-vitro stimulation of brain organoids with glucocorticoids shows upregulation of ZBTB16. KO of that gene blocks some effects of gccs #Epigenomics22 #epigenetics

Glucocorticoid response elements GREs show demethylation upon increased transcriptional response. Priming during pregnancy? #Epigenomics22 #epigenetics

Glucocorticoids given during pregnancy or as a result of stress can impact epigenetic marks in offspring - epigenetic "memory"?

#Epigenomics22 #epigenetics