Great to see our paper published @cddpress: „CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting“. Great collaboration!
@HelmholtzMunich
#cellpainting #deeplearning #ferroptosis

https://www.nature.com/articles/s41420-023-01559-y

Inducing #ferroptosis is a key approach to inhibiting #tumor progression, but how is it regulated? Study shows that #HBP1 #nanoparticles enter tumor cells, inducing ferroptosis & inhibiting #malignancy by regulating the HBP1-UHRF1-CDO1 pathway #PLOSBiology https://plos.io/3NEILSO

Out now in CDD: our work in collab with https://www.uni-wuerzburg.de/rvz/forschungsgruppen/ag-friedmann-angeli/ spearheaded by Thamara Nishida Xavier da Silva about in vitro, in silico and biophysical characterization of FSP1 inhibition #Ferroptosis #CellDeath

https://www.nature.com/articles/s41419-023-05787-z

MST and "iFSP1-Tracer" made it possible to quantify binding affinities of the highly hydrophobic inhibitor. The piperazine exit vector (A) could be a starting point for #targetedproteindegradation of FSP1. Huge thx and congrats to everyone involved!

Congrats to Karen Vousden and colleagues on their paper showing that sucralose/Splenda impairs T cell #immunity--here are my thoughts about the impact on #health and #diet, and a link to #ferroptosis. #cancer #Science https://brentstockwell.medium.com/this-sweetener-has-an-unexpected-impact-on-immunity-6a340b1c98f

Given knowledge of #ferroptosis, when we do human #diet studies, please separate effects of types of #fattyacids -- MUFAs, PUFAs and SFAs. Here are my thoughts on a recent paper that shows that diet quality is important, even for plant-based diets. https://medium.com/@brentstockwell/can-you-get-pancreatic-cancer-on-a-vegan-diet-6029c966d38

Excited to share my thoughts on our new paper in @NatureComms with Peter Canoll, Jeff Bruce, Simon Cheng and our lab members on a #precision #diet that promotes #ferroptosis in #brain #cancer @columbia @Columbia_Bio https://medium.com/@brentstockwell/a-precision-diet-for-brain-cancer-c03d1d5ed402

My thoughts on a fasting-mimicking #diet and #Alzheimers -- link to #ferroptosis? https://brentstockwell.medium.com/diet-alzheimers-and-protecting-the-brain-10e72617f737

I've wondered for 10+ years about how ferroptosis actually happens. Here is my explanation of our new paper in Nature Chemical Biology on the endoplasmic reticulum as the key site of lipid peroxidation during #ferroptosis - congrats to the whole team! https://brentstockwell.medium.com/the-critical-organelle-in-cells-that-drives-ferroptosis-479ed5d6dfa8

Congrats to Wan Seok Yang and his team on their paper analyzing #ferroptosis in motor neurons! Here are my thoughts and a link to his paper. #science #ALS @columbia_bio https://brentstockwell.medium.com/mouse-motor-neurons-derived-from-embryonic-stem-cells-undergo-ferroptosis-a-link-to-als-82969cebc490

Congrats to @PrattGroup @RedoxDKFZ @almut_schulze @AngeliFriedmann for discovering the role of hydropersulfides and other sulfate sulfur compounds in #ferroptosis -- My thoughts about this are here: https://brentstockwell.medium.com/can-sulfur-save-your-brain-c0d3c4e4f02

A recent paper by Tim Hammond's team at Sanofi showed that #microglia in the #brain undergo #ferroptosis and drive #neurodegeneration, such as #Parkinson's and #ALS. Here are my thoughts on why this is exciting. https://brentstockwell.medium.com/ferroptosis-of-microglia-drives-neurodegeneration-8046b6dbaa91

Here are thoughts on our new paper published today in @CellChemBiol on targeting #GPX4 to induce #ferroptosis -- link to free download available there. Congrats to the team & Enjoy! @columbia @Columbia_Bio #cancer #biochemistry https://brentstockwell.medium.com/a-new-way-to-target-gpx4-in-aggressive-cancers-28c4881b79ff

My #introduction — I’m a professor of #biology and #chemistry at #columbia #university in #nyc and chair of the department of biological sciences. My research is on #Ferroptosis #CellDeath #metabolism #cancer #neurodegeneration #ChemicalBiology and #drugdiscovery — I teach #biochemistry using #activelearning and #virtualreality — you can find my thoughts on #medium at https://brentstockwell.medium.com/honored-to-be-among-the-2022-highly-cited-researchers-534630086d93

A bit late, but here is my #introduction. I am biologist and a Group Leader @HelmholtzMunich. We study #CellDeath mechanisms and translate these findings into future drugs using #ChemicalBiology and #DrugDiscovery approaches. We are particularly interested in deciphering the cellular mechanisms controlling #Ferroptosis and characterizing regulators of #Ubiquitin Signaling in #CellDeath pathways. In addition, my lab operates the Compound Screening Platform with strong expertise in #HTS and #HCS.

A bit late, but here is my #introduction. I am biologist and a Group Leader @HelmholtzMunich. We study #CellDeath mechanisms and translate these findings into future drugs using #ChemicalBiology and #DrugDiscovery approaches. We are particularly interested in deciphering the cellular mechanisms controlling #Ferroptosis and characterizing regulators of #Ubiquitin Signaling in #CellDeath pathways. In addition, my lab operates the Compound Screening Platform with strong expertise in #HTS and #HCS.

Hi folks, let’s get the #hashtags #ferroptosis and #celldeath going here on Mastodon.

Hi folks, let’s get the #hashtags #ferroptosis and #celldeath going here on Mastodon.