Javier Díaz-Nido · @Javier_DN
170 followers · 351 posts · Server red.niboe.infoMultifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreich’s ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 342 posts · Server red.niboe.infoVatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 330 posts · Server red.niboe.infoShort-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 267 posts · Server red.niboe.infoNew Friedreich's Ataxia mouse model may aid research, therapy development
Mice house largest reported number of GAA repeats in Frataxin gene
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin
https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/
#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
162 followers · 225 posts · Server red.niboe.infoAbnormalities in sensory nerve cells tied to loss of coordination in Friedreich's Ataxia.
Limited growth of nerve fibers seen in Friedreich’s ataxia in cell study.
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Ataxia #FriedreichAtaxia #SensoryNeuron #NerveGrowth
https://friedreichsataxianews.com/news/abnormalities-sensory-nerve-cells-fa-tied-coordination-loss/
#NerveGrowth #SensoryNeuron #FriedreichAtaxia #ataxia #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Javier Díaz-Nido · @Javier_DN
131 followers · 138 posts · Server red.niboe.info
Study Traces Shared and Unique Cellular Hallmarks Found in 6 Neurodegenerative Diseases
Amyotrophic lateral sclerosis or Lou Gehrig’s disease, Alzheimer’s disease, Friedreich’s ataxia, frontotemporal dementia, Huntington’s disease and Parkinson’s disease harbor similar fundamental dysfunctional cellular processes.
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Brain #ALS #AmyotrophicLateralSclerosis #FriedreichAtaxia #Ataxia #HD #Huntington #PD #Parkinson #FTD #FrontoTemporalDementia #Alzheimer
https://neurosciencenews.com/cellular-process-neurodegeneration-22127/
#Alzheimer #FrontoTemporalDementia #FTD #parkinson #pd #huntington #hd #ataxia #FriedreichAtaxia #AmyotrophicLateralSclerosis #ALS #brain #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Javier Díaz-Nido · @Javier_DN
131 followers · 137 posts · Server red.niboe.info
Spinal Cord Abnormalities Correlate With Disease Severity in FA
Results show utility of MRI as biomarker in tracking disease progression
Damage to the spinal dorsal column seems developmental whereas damage of the corticospinal tract may be both developmental and degenerative in origin.
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurodevelopment #NeurodevelopmentalDisorders #Ataxia #FriedreichAtaxia #SpinalCord #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases
#MagneticResonanceImaging #MRI #Biomarker #BrainImaging
https://friedreichsataxianews.com/news/fa-spinal-cord-abnormalities-correlate-with-disease-severity/
#BrainImaging #Biomarker #mri #MagneticResonanceImaging #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #SpinalCord #FriedreichAtaxia #ataxia #neurodevelopmentaldisorders #neurodevelopment #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Javier Díaz-Nido · @Javier_DN
111 followers · 125 posts · Server red.niboe.infoReplay targets genetic brain disorders with new gene therapy company, Kaleibe, utilising big DNA HSV technology
#Biomedicine #GeneTherapy #GeneDelivery #MolecularTherapy #ViralVectors #HerpesviralVectors #HSV
#Neurogenetics #Parkinson #FriedreichAtaxia #Ataxia #NeurogeneticDiseases #GeneticDiseases #NeurologicalDiseases #NeurodegenerativeDiseases #BrainDiseases #Neurology #Neuroscience
https://replay.bio/news/replay-targets-genetic-brain-disorders
#neuroscience #neurology #BrainDiseases #NeurodegenerativeDiseases #NeurologicalDiseases #GeneticDiseases #NeurogeneticDiseases #ataxia #FriedreichAtaxia #parkinson #neurogenetics #hsv #HerpesviralVectors #ViralVectors #MolecularTherapy #GeneDelivery #genetherapy #biomedicine
Javier Díaz-Nido · @Javier_DN
108 followers · 116 posts · Server red.niboe.infoEfficacy of Omaveloxolone in Friedreich's Ataxia: Delayed-Start Analysis of the MOXIe Extension
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Brain #Cerebellum #RareDiseases #GeneticDiseases #FriedreichAtaxia #Ataxia
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29286
#ataxia #FriedreichAtaxia #GeneticDiseases #RareDiseases #Cerebellum #brain #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Javier Díaz-Nido · @Javier_DN
109 followers · 102 posts · Server red.niboe.info
Spinal cord magnetic resonance imaging and spectroscopy detect early-stage alterations and disease progression in Friedreich ataxia
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #FriedreichAtaxia #Ataxia #SpinalCord #RareDiseases #GeneticDiseases
#GeneticDiseases #RareDiseases #SpinalCord #ataxia #FriedreichAtaxia #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Javier Díaz-Nido · @Javier_DN
55 followers · 52 posts · Server red.niboe.info
Low Frataxin, Mitochondria Defects Prompt Cell Model Immune Response
Findings show new pathway that might contribute to #FriedreichAtaxia disease mechanisms.
#Neuroscience #Neurology #NeurodegenerativeDiseases #Ataxia #Mitochondria #Frataxin #ImmuneResponse #Interferon #cardiomyocyte #cardiomyopathy #HeartDisease
#GeneticDiseases #RareDiseases #Genetics
https://friedreichsataxianews.com/news/low-frataxin-mitochondria-defects-prompt-fa-immune-response/
#FriedreichAtaxia #neuroscience #neurology #NeurodegenerativeDiseases #ataxia #mitochondria #Frataxin #ImmuneResponse #Interferon #cardiomyocyte #cardiomyopathy #heartdisease #GeneticDiseases #RareDiseases #genetics