In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience

🚨#Optogenetic preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #optogenetics #neuroscience

Link:

Once in a while, I still wonder how a #GPCR with a fluorescent protein inserted in ICL3 can do any signaling.

RT @PiperProteins
#Render of the week is presenting a short molecular dynamics animation on #GPCR peptide binding process, prepared in @Blender using @bradyajohnston MolecularNodes, showing the ligand peptide (in blue) and receptor in black! #MD and #CryoEM data based on our recent paper 👇 (1/2)

Hi everyone! Time for an #introduction:
I’m a senior lecturer at #UnionCollege in NY. We’re a Primarily Undergraduate Institution #PUI where I teach #biochemistry, #molecularbiology, #Endocrinology, and other courses.
My research has 2 foci:
1) human #FSH receptor residency in #LipidRafts because I love #GPCR.
2) single nucleotide polymorphisms #snp in genes associated with #cortisol activity & their relationship with depression & obesity, especially as related to weight loss surgery #wls #rny

🚨 Don't miss this brand new article in Comms Biol spearheaded by Johanna Kaufmann exemplifying fast and easy detection of #GPCR #phosphorylation in 96-well format.

https://www.nature.com/articles/s42003-022-04135-9

Antibody phosphospecificity was confirmed by #peptide microarrays in our lab. Big thx and congrats to all co-authors! 😄
#research #collaboration #biophysics

Phosphospecific antibodies available at: https://7tmantibodies.com/

Many receptors, if not all, carry out biological functions via complex signaling. It usually involves several paths of synergistic or antagonistic readouts that define the functionality of these receptors. To better understand the biology of this complex system, especially when it comes to diseases where individual path contributes disproportionately, we need to differentiate the downstream paths in a clean system. This paper provides a rigorous solution.
#GPCR
https://www.nature.com/articles/s41467-022-34382-7

Where are all the #GPCR people? Anyone?