Julien Delpierre · @JulienDelpierre
180 followers · 214 posts · Server qoto.org
"[...] a tension-dependent signal on the #nucleus that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on #actomyosin #contractility, which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive #cPLA2 on the nuclear envelope and regulating the nuclear translocation of #cyclin B1.[...]"
https://rupress.org/jcb/article-abstract/221/12/e202205051/213539/Nuclear-tension-controls-mitotic-entry-by
#BioMechanics #MechanoBiology #NuclearTension #CellBiology #CellCycle #CellDivision #NuclearEnvelope #NuclearTranslocation #CellCompression #GenomicInstability
#cPLA2 #biomechanics #mechanobiology #NuclearTension #cellbiology #NuclearTranslocation #CellCompression #nucleus #actomyosin #contractility #cyclin #cellcycle #celldivision #NuclearEnvelope #GenomicInstability