Tetramerization of AMPA-receptors - almost no effect of TARPs. I start to wonder what they are for...solid work as ever from the Wollmuth lab.

https://www.jbc.org/article/S0021-9258(23)02255-X/fulltext

#GlutamateReceptors #IonChannels

Compare with simulations on AMPARs (using the multisite model) where we readily see Ca2+ permeation, and confirmed water statistics and polarisation effects with QM/MM.

In classical force fields, calcium doesn't move, it just gets stuck (see: https://www.nature.com/articles/s41467-020-14573-w). In contrast, the multisite model is accurate in energy and validated in hydration statistics.

https://chemrxiv.org/engage/chemrxiv/article-details/631f1665faf4a4165e0f0d5f

#biophysics #GlutamateReceptors #MolecularDynamics #dynion #Electrophysiology #ionchannels #calcium