Hello world!
For a year we've been working together with UN-OCHA to make #earthobservation derived #climate #data more accessible.
I'm very excited to share we've published over 100 climate datasets, tailored for humanitarian use, to OCHA's #HDX platform 🎉
To read more about this collaboration and the datasets, check out their blogpost: centre.humdata.org/wfp-climate-da…
#earthobservation #climate #data #HDX
🚨 Preprint
Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity
http://biorxiv.org/cgi/content/short/2022.12.21.521430v1?rss=1
#structuralbiology #SAXS #HDX #NMR #Science
Hey Structural Biologists :protein:
#crystallography #MX #CryoEM #CryoET #NMR #SAXS #HDX #Alphafold #PDB #EMDB #StructuralBiology
I have created a group @strucbio .
If you tag this account in any relevant toot, it will automatically boost it.
So if you follow this account, any toots about structural biology should end up in your TL. The more people use it, the better it will be.
Boosting appreciated. :protein:
#crystallography #mx #cryoem #cryoET #NMR #SAXS #HDX #AlphaFold #pdb #emdb #structuralbiology
Another Wilson group Research retrospective! This one is actually a big review in #ACS #chemicalreviews which bills itself (mostly correctly) as the 'Journal of Record' for 'state of the field' reviews in Chemistry...
Here's our take on "Subsecond Time-resolved #HDX #massspectrometry in Dynamic Structural Biology". I'm proud to say that this paper was dubbed 'provocative' by one reviewer and also features what looks like a leopard pooping a protein in the TOC figure.
#acs #chemicalreviews #HDX #massspectrometry
#introduction I am a research scientist at the #BroadInstitute in #Cambridge with an interest in #Ubiquitin #ligase #structuralbiology and #mechanisms. Here for the #science toots about #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #CryoEM
#introduction #broadinstitute #Cambridge #Ubiquitin #ligase #structuralbiology #mechanisms #Science #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #cryoem
Time for another Research Retrospective! For #science ! This relatively recent paper is where we 'prove' (suggest) that you can predict where neutralizing antibodies will bind their antigens, by watching what happens when the antigen ( #COVID19 spike) binds it's target (human ACE2).
Using #massspec #HDX , when Spike binds ACE2, regions that aren't at the binding site change how they move... and that's where neutralizing #antibodies bind! #massspectrometry #biochemistry
#Science #covid19 #massspec #HDX #antibodies #massspectrometry #biochemistry
How does #biophysics constrain #protein #evolution? We found two sites co-evolving to avoid a deleterious stabilizing contact. Across orthologs, phenylalanine is at either site, but not both at once. When we put two Phe together, they form a molecular staple that distorts structure and disrupts function. A non-native structure is within ~10 kJ/mol of native structure--a negative design constraint on evolving proteins!
https://doi.org/10.1073/pnas.2208029119 #nmr #hdx #bioinformatics
#biophysics #protein #Evolution #NMR #HDX #bioinformatics
Hello, I am a Bioanalytical Mass Spectrometrist from Canada @ York University. I think this Mastodon is neat, so I'm going to post sciency stuff here, including our super-awesome papers from my group.
Our main thing is to use our own version of hydrogen deuterium exchange #HDX to explore how proteins change change shape and move differently when they function or in diseases like #Alzheimer's, #Parkinson's, #ALS and #cancer.
#science #Biochemistry #proteins #chemistry #biology #canada
#HDX #Alzheimer #Parkinson #ALS #cancer #Science #biochemistry #proteins #chemistry #biology #canada
A late #StructuralBiology #followfriday.
(We should try and help each other reconnect)
@graemewinter
@SjorsScheres
@terwilltom
@aragaod
@MirandaLynchPhD
@james
#Crystallography #CryoEM #NMR #SAXS #HDX add your name and anyother contacts below.
Please boost!
#HDX #SAXS #NMR #cryoem #crystallography #followfriday #structuralbiology