valpesendorfer · @valpesendorfer
3 followers · 1 posts · Server fosstodon.org

Hello world!

For a year we've been working together with UN-OCHA to make derived more accessible.

I'm very excited to share we've published over 100 climate datasets, tailored for humanitarian use, to OCHA's platform 🎉

To read more about this collaboration and the datasets, check out their blogpost: centre.humdata.org/wfp-climate-da…

#earthobservation #climate #data #HDX

Last updated 1 year ago

Stefan Savelsberg · @schnabel
65 followers · 84 posts · Server mastodontech.de

Blocking aria.microsoft.com and others using will break Microsoft when using the optimized version for .

#pihole #teams #HDX #citrix

Last updated 2 years ago

Dave Briggs :protein: · @xtaldave
1132 followers · 2891 posts · Server xtaldave.net

🚨 Preprint
Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity
biorxiv.org/cgi/content/short/

@strucbio

#structuralbiology #SAXS #HDX #NMR #Science

Last updated 2 years ago

Dave Briggs :protein: · @xtaldave
959 followers · 1853 posts · Server xtaldave.net

Hey Structural Biologists :protein:

I have created a group @strucbio .

If you tag this account in any relevant toot, it will automatically boost it.

So if you follow this account, any toots about structural biology should end up in your TL. The more people use it, the better it will be.

Boosting appreciated. :protein:

#crystallography #mx #cryoem #cryoET #NMR #SAXS #HDX #AlphaFold #pdb #emdb #structuralbiology

Last updated 2 years ago

Dowdwilson · @dowdwilson
67 followers · 235 posts · Server toot.community

Another Wilson group Research retrospective! This one is actually a big review in which bills itself (mostly correctly) as the 'Journal of Record' for 'state of the field' reviews in Chemistry...

Here's our take on "Subsecond Time-resolved in Dynamic Structural Biology". I'm proud to say that this paper was dubbed 'provocative' by one reviewer and also features what looks like a leopard pooping a protein in the TOC figure.

pubs.acs.org/doi/abs/10.1021/a

#acs #chemicalreviews #HDX #massspectrometry

Last updated 2 years ago

Katherine Reiter · @kreiter
86 followers · 4 posts · Server mstdn.science
Dowdwilson · @dowdwilson
59 followers · 168 posts · Server toot.community

Time for another Research Retrospective! For ! This relatively recent paper is where we 'prove' (suggest) that you can predict where neutralizing antibodies will bind their antigens, by watching what happens when the antigen ( spike) binds it's target (human ACE2).

Using , when Spike binds ACE2, regions that aren't at the binding site change how they move... and that's where neutralizing bind!

pubs.acs.org/doi/full/10.1021/

#Science #covid19 #massspec #HDX #antibodies #massspectrometry #biochemistry

Last updated 2 years ago

Mike Harms · @EvolBiochemist
163 followers · 58 posts · Server ecoevo.social

How does constrain ? We found two sites co-evolving to avoid a deleterious stabilizing contact. Across orthologs, phenylalanine is at either site, but not both at once. When we put two Phe together, they form a molecular staple that distorts structure and disrupts function. A non-native structure is within ~10 kJ/mol of native structure--a negative design constraint on evolving proteins!

doi.org/10.1073/pnas.220802911

#biophysics #protein #Evolution #NMR #HDX #bioinformatics

Last updated 2 years ago

Dowdwilson · @dowdwilson
59 followers · 168 posts · Server toot.community

Hello, I am a Bioanalytical Mass Spectrometrist from Canada @ York University. I think this Mastodon is neat, so I'm going to post sciency stuff here, including our super-awesome papers from my group.

Our main thing is to use our own version of hydrogen deuterium exchange to explore how proteins change change shape and move differently when they function or in diseases like 's, 's, and .

#HDX #Alzheimer #Parkinson #ALS #cancer #Science #biochemistry #proteins #chemistry #biology #canada

Last updated 2 years ago

Dave Briggs :protein: · @xtaldave
692 followers · 913 posts · Server xtaldave.net

A late .

(We should try and help each other reconnect)

@graemewinter
@SjorsScheres
@terwilltom
@aragaod
@MirandaLynchPhD
@james

add your name and anyother contacts below.

Please boost!

#HDX #SAXS #NMR #cryoem #crystallography #followfriday #structuralbiology

Last updated 2 years ago