'The colonization of our stomachs by #Helicobacter pylori is believed to predate the oldest splits between extant human populations. We identify a Hardy ecospecies of H. pylori associated with indigenous groups, isolated from people in Siberia, Canada, and USA.'

#Preprint #EvolutionaryBiology

https://www.biorxiv.org/content/10.1101/2023.04.28.538659v3

"We have established a #Helicobacter-induced accelerated disease progression mouse model, which involves infecting mice deficient in the myeloid differentiation primary response 88 gene (Myd88-/-) with H. felis. Using this model, we report here that that progression of H. felis-induced inflammation to high-grade dysplasia was associated with activation of type I interferon (IFN-I) signaling pathway and upregulation of related downstream target genes, IFN-stimulated genes (ISGs)." #Preprint

https://www.biorxiv.org/content/10.1101/2023.06.04.543598v1?med=mas

'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'

#Helicobacter #InnateImmunity #HostPathogen

https://www.nature.com/articles/s41572-023-00431-8

#Helicobacter ailurogastricus in patient with multiple refractory gastric #ulcers, #Japan #EID journal, #CDC
https://bit.ly/3lqJ8X9

Nur noch eine #Erstlinientherapie in neuer #Leitlinie: Paradigmenwechsel bei #Helicobacter pylori: Infektion allein ist eine Krankheit https://www.deutsche-apotheker-zeitung.de/news/artikel/2021/12/01/paradigmenwechsel-bei-helicobacter-pylori-infektion-allein-ist-eine-krankheit