CRISPR-activated Oct4 as #GeneTherapy for #Progeria (LmnaC698G) & natural aged🐭
#HutchinsonGilfordProgeriaSyndrome

Polyethylenimine-cationic gold nanoparticle iv.

Do we need an aortotropic vector for #AorticAneurysm?

Dr. Jongpil Kim lab @AgingCell 2023
https://onlinelibrary.wiley.com/doi/10.1111/acel.13825

Through Oct4 expression is only transiently activated for 2 weeks in 50% aortic SMCs (by day 5 delivery) in progeria mice, but with an amazing long-lasting benefits on SMC vitality, arterial stiffness, progerin, multi-organ ( kidney, spleen, muscle, lung, and skin) senescence transcriptional profile, lifespan w/o apparent dysplasia

#HutchinsonGilfordProgeriaSyndrome #Aorta

Material & Structural #Biomechanics of large arteries of #Progeria🐭LmnaC609G/C609G

Crucial insights into regionalized mechano-vulnerability of elastic arteries in #Progeria

Dr. Jay Humphrey lab bioRxiv 2023
https://www.biorxiv.org/content/10.1101/2023.01.10.523266v1.full