A highly intriguing #Hyperglycemia-#HyaluronicAcid-CD44-Survivin cascade dictates β-islet survival

4-methylumbelliferone, an HA biosynthesis inhibitor, protects diabetic🐭(db/db; STZ 40 mg) from hyperglycemia😎

Dr. Paul Bollyky lab BioRxiv 2023
https://www.biorxiv.org/content/10.1101/2023.02.28.530522v1.full

Want to know about this drug 4-methylumbelliferone/#Hymecromone?👇

4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer

Front Immunol 2015
https://www.frontiersin.org/articles/10.3389/fimmu.2015.00123/full

#ArterioVenousFistula #EndMT

Low #OscillatoryShearStress->
⏫Osteopontin-CD44 in #EndothelialCell->
⏫EndMT->
⏫24% of neointimal cells at rat aortocaval junction

A cascade independent of #HyaluronicAcid🤓

Dr. Yung-Hsin Yeh lab Kidney Int 2023
https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext