Secukinumab blocks IL-17 and some evidence of efficacy in hidradenitis suppurativa in 2x RCT.

Interesting in so much this is clearly an inflammatory disease in which there is also undoubtedly an infective component.

These studies, along with efficacy of TNF blockade indicates hyperinflammation the main issue.

#immunology #inflammation #hidradenitis #IL17 #secukinumab #RCT #trial #hyperinflammation

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00022-3/fulltext?dgcid=raven_jbs_aip_email

Pretty stunning paper proposing a mechanism for #MIS-C in children post-Covid-19.

Genetic deficiency in OAS–RNase L promotes myeloid cell cytokine production +++.

#COVID19 #immunology #inflammation #hyperinflammation

https://www.science.org/doi/10.1126/science.abo3627

Time to introduce myself. I am a mother of two. Head of a pediatric intensive care unit and active in a consultant team responsible for Picu and NICU. my interests are #Immunology, #Hyperinflammation,#Misc and #PedsICU